| 3-乳糖基-5,6-二甲基-4-羰基-噻吩并[2,3-d]嘧啶-2-硫醇钠的合成 |
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| 引用本文： | 戴秋红,刘明国.3-乳糖基-5,6-二甲基-4-羰基-噻吩并[2,3-d]嘧啶-2-硫醇钠的合成[J].三峡大学学报(自然科学版),2012,34(5):92-94. |
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| 作者姓名： | 戴秋红 刘明国 |
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| 作者单位： | 三峡大学 化学与生命科学学院,湖北宜昌,443002 |
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| 摘 要： | 2-氨基-4,5-二甲基噻吩-3-甲酸乙酯1与七乙酰基乳糖基异硫氰酸酯2在干燥的乙腈溶液中发生亲核加成反应,生成七乙酰基乳糖基硫脲中间体3.后者在甲醇/甲醇钠催化条件下,同时发生环化和酯交换反应,生成水溶性良好的3-乳糖基-5,6-二甲基-4-羰基-噻吩并2,3-d]嘧啶-2-硫醇钠4目标化合物.
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| 关 键 词： | 氨基噻吩酯 七乙酰乳糖基异硫氰酸酯 硫脲 氮苷 合成 |
Synthesis of the Sodium 3-Lactosyl-5,6-Dimethyl-4-oxo-Thieno [-2,3-d] pyrimidine-2-Thiolate |
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| Dai Qiuhong
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Liu Mingguo.Synthesis of the Sodium 3-Lactosyl-5,6-Dimethyl-4-oxo-Thieno [-2,3-d] pyrimidine-2-Thiolate[J].Journal of China Three Gorges University(Natural Sciences),2012,34(5):92-94. |
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| Authors: | Dai Qiuhong Liu Mingguo |
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| Institution: | Dai Qiuhong Liu Mingguo (College of Chemistry ＆ Life Science, China Three Gorges Univ. , Yichang 443002, China) |
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| Abstract: | The nueleophilic additional reaction of ethyl 2-amino-4,5-dimethyl-thiophene-3-carboxylate 1 with hetpa-O-acetyl-lactosyl isothiocyanate 2 produced the betpa-O-acetyl-lactosyl thiourea intermediate 3 in anhy- drous solution of acetonitrile. At the CH3OH/CH3ONa condition, the later was underwent cyclization and ester exchanged reaction simultaneously, and was converted to the target compound sodium 3-Lactosyl-5,6-dim- ethyl-4-oxo-thieno2,3-d]pyrimidine-2-thiolate 4, which had good solubility in water. |
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| Keywords: | aminothiophene ester hetpa-O-acetyl-lactosyl isothiocyanate thiourea N-glycoside synthesis |
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