| 抗菌药甲磺酸帕珠沙星的合成 |
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| 引用本文： | 申绪湘,彭晓春,龚兴浪,肖竹平,王迎春,李志平.抗菌药甲磺酸帕珠沙星的合成[J].吉首大学学报(自然科学版),2009,30(5):96-100. |
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| 作者姓名： | 申绪湘 彭晓春 龚兴浪 肖竹平 王迎春 李志平 |
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| 作者单位： | （1.吉首大学党委宣传部，湖南 吉首 416000；2.吉首大学化学化工学院，湖南 吉首 416000） |
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| 基金项目： | 湖南省教育厅科学研究项目 |
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| 摘 要： | 以左旋氧氟沙星中间体 （(S)-9,10-二氟-3-甲基-2,3-二氢-7-氧代-7-H-吡啶并1,2,3-de]1,4]苯并噁嗪-6-羧酸乙酯）为起始原料，经亲核取代、选择性脱羧、环丙化、水解反应、Hofmann重排和成盐单元反应合成了甲磺酸帕珠沙星，经HPLC检测，质量浓度为91.352 g/L.优化后的工艺过程适合工业化批量生产.
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| 关 键 词： | 抗菌剂 甲磺酸帕珠沙星 合成 |
Synthesis of Antimicrobial Pazufloxacin Mesilate |
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| SHEN Xu-xiang,PENG Xiao-chun,GONG Xing-lang,XIAO Zhu-ping,WANG Ying-chun,LI Zhi-ping.Synthesis of Antimicrobial Pazufloxacin Mesilate[J].Journal of Jishou University(Natural Science Edition),2009,30(5):96-100. |
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| Authors: | SHEN Xu-xiang PENG Xiao-chun GONG Xing-lang XIAO Zhu-ping WANG Ying-chun LI Zhi-ping |
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| Institution: | (1.Party Committee Propaganda Department,Jishou University,Jishou 416000,Hunan China;2.Department of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,Hunan China) |
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| Abstract: | 〗Pazufloxacin mesilate was synthesized from (S)-9,10-difluoro-3-methly-7-oxo-2,3-dihydro-7-H-pyrido1,2,3-de]1,4] benzoxazine-6-carboxylate with nuclephilic substitution,selective decarboxylation,cyclic addition,hydrolysis,Hofmann recomposition and salt formation.The product was tested by HPLC and the results showed content of 91.352 g/L.The optimized process is suitable for industrial mass production. |
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| Keywords: | antimicrobial pazufloxacin mesilate synthesis |
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