| 头孢地嗪酸的合成 |
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| 引用本文： | 高国庆,郑庚修,张淑芳.头孢地嗪酸的合成[J].济南大学学报(自然科学版),2009,23(2). |
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| 作者姓名： | 高国庆 郑庚修 张淑芳 |
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| 作者单位： | 济南大学,化学化工学院,山东,济南,250022 |
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| 摘 要： | 以氨噻肟酸和二乙氧基硫代磷酰氯为原料,在碱性条件下,制得新活性酯二乙氧基硫代磷酰-(Z)-(2-氨基噻唑-4-基)甲氧亚氨基乙酸酯溶液(DPS溶液);与7-氨基-3-(5-羧甲基-4-甲基-1,3-噻唑-2-巯甲基)头孢-2-烯-2-羧酸(TACS)直接反应,合成头孢地嗪酸,以TACS计产品收率达69.2%(HPLC检测,纯度大于99.0%).
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| 关 键 词： | 头孢地嗪酸 新活性酯 合成 |
Synthesis of Cefodizime Acid |
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| GAO Guo-qing,ZHENG Geng-xiu,ZHANG Shu-fang.Synthesis of Cefodizime Acid[J].Journal of Jinan University(Science & Technology),2009,23(2). |
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| Authors: | GAO Guo-qing ZHENG Geng-xiu ZHANG Shu-fang |
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| Institution: | School of Chemistry and Chemical Engineering;University of Jinan;Jinan 250022;China |
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| Abstract: | 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid reacted with diethylthiophosphoryl chloride in the presence of a base to form diethylthiophosphoryl-(Z)-(2-aminothiazole-4-yl)-syn-methoxyiminoacetate solution(DPS solution).Cefodizime acid was prepared by the one-step synthesis from 7-amino-3-(5-(carboxymethyl-4-methyl-1,3-thiazolyl-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid(TACS) and the DPS solution.The yield of cefodizime acid reached in 69.2%(monitored by HPLC,purity>99.0%). |
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| Keywords: | cefodizime acid new activity ester synthesis |
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