4-羟基苯基卟吩的合成和分离方法改进

对单羟基苯基卟吩 5- ( 4- 羟基苯基) - 10, 15, 20- 三苯基- 21H, 23H- 卟吩( H2TPPOH) ] 和多羟基苯基卟吩 5, 10- 二( 4- 羟基苯基) - 15, 20- 二苯基- 21H, 23H- 卟吩(H²TPP( OH) ₂) 、 5- 苯基- 10, 15, 20- 三( 4- 羟基苯基) - 21H,23H- 卟吩( H₂TPP( OH) ₃) ] 的分离方法作了改进.实验表明, 分离各种羟基苯基卟吩, 产物纯度高,分离效果好,并可节省大量洗脱剂,缩短了柱分离时间
同时,还考察了配料比, 吡咯溶液的滴加速度和操作方式对合成各种羟基苯基卟吩产率的影响采用3:1.05:4( 苯甲醛:对羟基苯甲醛: 吡咯,摩尔比) , 3 min 滴完吡咯溶液,强烈的电动搅拌, 可提高H₂TPPOH 的收率.

Improve on Method of Separation and Synthesis of 4-Hydroxyphenyl-21H,23H-Porphine

Method of separat ion of a hydroxyphenyl- 21H, 23H- porphine 5- ( 4- hydroxyphenyl) - 10, 15, 20-triphenyl- 21H, 23H- porphine( H₂TPPOH) ] and many hydroxyphenyl- 21H, 23H- porphine 5, 10- di( 4- hydroxyphenyl) - 15, 20- diphenyl- 21H, 23H- porphine( H₂TPP( OH) 2) ; 5- phenyl- 10, 15, 20- tri( 4- hydrox yphenyl) - 21H, 23H- porphine( H₂TPP( OH) ₃) ] was improved.The results showed that in the course of separating all kinds of hydroxyphenyl porphine, by the new method, the separate efficiency and product purity were better, the using amount of eluant was less and the column separation times was shorter. In addition, the influence of the ratio of reactants, drop speed of pyrrole solution and operational method on the yield of synthesing all kinds of hydroxyphenyl porphine were inves  tigated,wi th 3:1. 05:4( C₆H₄CHO: HOC₆H₄CHO:C₄H₅N, mole ratio) , drop pyrrole solution in 3 minutes and strong motor stir, the yield of the H₂TPPOH was increased.