钳形配体2-溴-1,3-双[2-(5-乙氧基)噁唑基]苯的合成研究

使用不同种类常规脱水剂实现了钳形配体2-溴-1,3-双2-(5-乙氧基)噁唑基]苯的合成,但反应条件剧烈,反应时间较长,产率中等,而使用PPh3-I2体系来实现这一环化反应时获得了95%的高产率,这一体系不需特殊试剂和苛刻的反应条件温,用于α-酰胺基酯的环化,是Robinson-Gabriel噁唑合成法的有用扩展.

Synthesis of Pincer Ligand of 2-bromo-1,3-bis(5-ethoxy-oxazol-2-yl) Benzene

Pincer ligand of 2-bromo-l, 3-bis (5-ethoxy-oxazol-2-yl) benzene was synthesized using various common dehydration agent, but these procedures required severe conditions and long reaction time, and just got moderate yields. While as PPh_3 -I_2 system was applied in this reaction, excellent yield of 95% was achieved. This system requires neither uncommon regent nor severe conditions used to cyclize cramido ester, which can serve as the expanding of Robinson-Gabriel oxazole synthesis.