| 刺五加对大鼠脑缺血损伤修复作用的研究 |
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| 引用本文： | 林洪,王有为,邢玉芝,杨玲麟,胡火珍.刺五加对大鼠脑缺血损伤修复作用的研究[J].四川大学学报(自然科学版),2006,43(1):217-221. |
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| 作者姓名： | 林洪 王有为 邢玉芝 杨玲麟 胡火珍 |
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| 作者单位： | 四川大学生命科学学院,细胞生物学教研室,成都,610064 |
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| 基金项目： | 四川省攻关项目(03SG022-002-2) |
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| 摘 要： | 采用双侧颈总动脉结扎制作SD大鼠暂时性全脑缺血模型,手术后尾静脉分别注射药物刺五加注射液或生理盐水进行观察和神经行为学评分,制片作常规HE染色和Nestin免疫组化染色检测缺血损伤后的修复情况.神经行为学评分显示刺五加组神经功能恢复明显好于生理盐水组.脑缺血再灌注后3d时海马、室管膜和室管膜下区神经干细胞有少量Nestin阳性表达;脑缺血再灌注后5d和7d时海马、室管膜、室管膜下区和缺血区神经干细胞阳性Nestin阳性细胞数明显增加,尤其在缺血区,刺五加组Nestin阳性表达细胞数显著多于生理盐水对照组.
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| 关 键 词： | 刺五加 脑缺血 神经干细胞 巢蛋白 |
| 文章编号： | 0490-6756（2006）01-0217-05 |
| 收稿时间： | 2005-07-16 |
| 修稿时间： | 2005-07-16 |
Effects of Acanthopanax Senticosus Injection on the Cerebral Ischemia in Rats |
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| LIN Hong,WANG You-wei,XING Yu-zhi,YANG Ling-lin,HU Huo-zhen.Effects of Acanthopanax Senticosus Injection on the Cerebral Ischemia in Rats[J].Journal of Sichuan University (Natural Science Edition),2006,43(1):217-221. |
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| Authors: | LIN Hong WANG You-wei XING Yu-zhi YANG Ling-lin HU Huo-zhen |
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| Institution: | Laboratory of Cell-biology; College of life science; Sichuan University;Laboratory of Cell-biology; College of life science; Sichuan University;Laboratory of Cell-biology; College of life science; Sichuan University;Laboratory of Cell-biology; College of life science; Sichuan University;Laboratory of Cell-biology; College of life science; Sichuan University |
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| Abstract: | To investigate the effects of acanthopanax senticosus on the proliferation of the neural stem cells after cerebral ischemia reperfusion in SD rats,the temporary cerebral ischemia model was established by common carotid arteries occlusion.The acanthopanax senticosus or saline were injected into rats through trail vein after operation.The behavior of the operated rats were observed and the neurologic scores 2 hours after ischemic reperfusion were assessed respectively.The slices were stained with hematoxylin |
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| Keywords: | acanthopanax senticosus cerebral ischemia neuronal stem cell nestin |
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