| 2,5-二吡啶基-1,3,4-噁二唑的合成 |
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| 引用本文： | 何心伟,周尧,于智宇,方梅,商永嘉.2,5-二吡啶基-1,3,4-噁二唑的合成[J].阜阳师范学院学报(自然科学版),2014(2):26-28. |
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| 作者姓名： | 何心伟 周尧 于智宇 方梅 商永嘉 |
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| 作者单位： | 安徽师范大学化学与材料科学学院、功能分子固体教育部重点实验室、安徽分子基材料省级实验室,安徽芜湖241000 |
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| 基金项目： | 基金项目：国家自然科学基金项目（21172001,21372008）;教育部新世纪优秀人才计划（NCET-10-0004）;安徽省自然科学基金项目（1308085QB39）资助. |
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| 摘 要： | 以烟酸/异烟酸为原料,经由酰化、肼解、关环三步反应合成了2,5-二吡啶基-1,3,4-噁二唑,每步收率均在80%以上。该合成路线原料易得,实验条件温和,操作简单等优点,是实验室制备2,5-二吡啶基-1,3,4-噁二唑的一种简便可行的方法。
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| 关 键 词： | -噁二唑 合成 双酰肼 关环反应 |
Synthesis of 2,5-Dipyridyl-1,3,4-oxadiazoles |
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| HE Xin-wei,ZHOU Yao,YU Zhi-yu,Fang Mei,SHANG Yong-jia.Synthesis of 2,5-Dipyridyl-1,3,4-oxadiazoles[J].Journal of Fuyang Teachers College:Natural Science,2014(2):26-28. |
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| Authors: | HE Xin-wei ZHOU Yao YU Zhi-yu Fang Mei SHANG Yong-jia |
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| Institution: | ( The Key Labortatory of Functional Molecular Solids Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu Anhui 241000, China) |
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| Abstract: | 2,5-dipyridyl-1,3,4-oxadiazoles were synthesized from nicotinic acid/ isonicotinic acid through acylation, hydra-zine decomposition and ring-closing reaction, and each step yields were above 80% . This method has such advantages as mild reac-tion conditions, simplified operational procedure and easiness in getting the raw materials. What’s more, it can be carried out under mild conditions applicable for the productions in the laboratory. |
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| Keywords: | 1 3 4-Oxadiazoles synthesis Diarylhydrazide ring-closing reaction |
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