| 1-环丙基-6,7-二氟-8-甲氧基-1,4-二氢-4-氧代喹啉-3-羧酸乙酯的制备 |
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| 引用本文： | 母晓明,李瑞军.1-环丙基-6,7-二氟-8-甲氧基-1,4-二氢-4-氧代喹啉-3-羧酸乙酯的制备[J].洛阳大学学报,2003,18(4):39-42. |
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| 作者姓名： | 母晓明 李瑞军 |
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| 作者单位： | 郑州大学,化学系,河南,郑州,450002 |
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| 摘 要： | 合成1-环丙基-6，7-二氟-8-甲氧基-1，4-二氢-4-氧代喹啉-3-羧酸乙酯．以四氟邻苯二甲酸为起始原料，经水解、部分脱羧、甲基化、酸化得到中间体2，4，5-三氟-3-甲氧基苯甲酸．中间体再经酰氯化、缩合、脱羧、醚化、环丙胺置换，环合得本品．实验收率为37．7％，本法工艺简单，易操作．
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| 关 键 词： | 1-环丙基-6，7-二氟-8-甲氧基-1，4-二氢-4-氧代喹啉-3-羧酸乙酯 四氟邻苯二甲酸 2，4，5-三氟-3-甲氧基苯甲酸 中间体 合成 氟喹诺酮类药物 抗菌药 |
| 文章编号： | 1007-113X(2003)04-0039-04 |
| 修稿时间： | 2003年11月16 |
Preparation of 1-cyclopropyl-6,7-difluoro-8-methoxyl - 1,4-dihydro-4-oxoquinline-3-ethyl Carboxylate |
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| MU Xiao-ming,LI Rui-jun.Preparation of 1-cyclopropyl-6,7-difluoro-8-methoxyl - 1,4-dihydro-4-oxoquinline-3-ethyl Carboxylate[J].Journal of Luoyang University,2003,18(4):39-42. |
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| Authors: | MU Xiao-ming LI Rui-jun |
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| Abstract: | The l-cyclopropyl-6,7-difluoro-8-methoxyl-1,4-dihydro-4-oxoquinline-3-ethyl carboxylate has been discussed. The initiative stuff is tetrefluoro-phthalic acid. By means of hydrolyzation, partly decarboxylation, methyla-tion, acidification the intermediate product, 2,4,5-trifluoro-3-methoxyl benzoic acid can be got. The final product is got by reactions of acylchloridization, condensation, decarboxylation, etherealization, cyclopropylamine replacement and cyclization of the intermediate product. The efficiency of this synthesis is 37.7% . The technique of this method is simple and easy to be handle. |
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| Keywords: | tetrefluoro-phthalic acid 2 4 5-trifluoro-3-methoxyl benzoic acid l-cyclopropy-6 7-difluoro-8-methoxyl-1 4-dihydro-4-oxoquinline-3-ethyl carboxylate intermediate product synthesis |
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