| 再生丝素蛋白-壳聚糖包药微囊的质量研究 |
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| 引用本文： | 张幼珠,雷晓英,王新波,李建.再生丝素蛋白-壳聚糖包药微囊的质量研究[J].东华大学学报(自然科学版),2003,29(5):117-121. |
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| 作者姓名： | 张幼珠 雷晓英 王新波 李建 |
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| 作者单位： | 1. 苏州大学材料工程学院,江苏,苏州,215021
2. 苏州市疾病预防控制中心,江苏,苏州,215003 |
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| 摘 要： | 以模型药物消炎痛(吲哚美辛)作为芯料，在W／O型乳化体系中分别以复凝聚法制备再生丝素蛋白-壳聚糖包药微囊和以单凝聚法制备壳聚糖包药微囊，测试并分析了两种微囊的形貌、粒径、成囊率、包囊率和释药率等质量指标。结果表明，丝素-壳聚糖包药微囊的成囊率、包囊率比壳聚糖包药微囊高，药物缓释效果更好。
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| 关 键 词： | 再生丝素蛋白-壳聚糖微囊 吲哚美辛 质量 缓释 包药微囊 复凝聚法 单凝聚法 微胶囊 |
| 修稿时间： | 2002年10月25 |
Study on the Quality of Medicine Microcapsule Wrapped with Regenerated Fibroin Protein-Chitosan |
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| ZHANG You zhu ,LEI Xiao ying ,WANG Xin bo ,LI Jian.Study on the Quality of Medicine Microcapsule Wrapped with Regenerated Fibroin Protein-Chitosan[J].Journal of Donghua University,2003,29(5):117-121. |
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| Authors: | ZHANG You zhu LEI Xiao ying WANG Xin bo LI Jian |
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| Institution: | ZHANG You zhu 1,LEI Xiao ying 1,WANG Xin bo 1,LI Jian 2 |
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| Abstract: | Using Indomethacin as core material in the W/O emulsion system, two kinds of medicine microcapsule are prepared. One is wrapped with regenerated fibroin Protein Chitosan using complex coacervation method, the other is wrapped with Chitosan using simple coacervation method. The morphology,granule size, capsule formulation efficiency, capsule wrapped efficience,medicine release efficience and other quality parameters of the two microcapsule stated above were tested and analyzed. The results show that capsule formulation efficiency and capsule wrapped efficiency of the medicine microcapsule wrapped with fibroin Protein Chitosan are higher than those of which wrapped with Chitosan,and consequently the effect of the medicine slow release of the former is better than that of the latter. |
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| Keywords: | regenerated fibroin protein chitosan microcapsule chitosan microcapsule indomethacin quality medicine slow release |
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