| 噻唑烷-4-酮衍生物抗HCMV和VZV的活性 |
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| 引用本文： | 吕树芳,赵莲,陈华.噻唑烷-4-酮衍生物抗HCMV和VZV的活性[J].河北大学学报(自然科学版),2011,31(3):280-283. |
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| 作者姓名： | 吕树芳 赵莲 陈华 |
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| 作者单位： | 河北大学化学与环境科学学院河北省化学生物学重点实验室,河北保定,071002 |
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| 基金项目： | 河北省自然科学基金资助项目 |
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| 摘 要： | 利用病毒噬斑抑制法,探讨了2,3-二芳基-1,3-噻唑烷-4-酮(化合物1和2)、含糖基的1,3-噻唑烷-4-酮(化合物3和4)抗人巨细胞疱疹病毒(HCMV)和水痘带状疱疹病毒(VZV)活性.结果表明:2,3-二芳基-1,3-噻唑烷-4-酮是一类新型高效的抗HCMV化合物,而含糖基的1,3-噻唑烷-4-酮可能是一类比较...
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| 关 键 词： | 噻唑烷-4-酮 人巨细胞疱疹病毒 水痘带状疱疹病毒 |
Activity Studies of Thiazolidin-4-ones Against HCMV and VZV |
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| L Shu-fang,ZHAO Lian,CHEN Hua.Activity Studies of Thiazolidin-4-ones Against HCMV and VZV[J].Journal of Hebei University (Natural Science Edition),2011,31(3):280-283. |
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| Authors: | L Shu-fang ZHAO Lian CHEN Hua |
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| Institution: | L(U) Shu-fang,ZHAO Lian,CHEN Hua |
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| Abstract: | 2,3-Diaryl-1,3-thiazolidin-4-ones(compounds 1 and 2) and 1,3-thiazolidin-4-ones bearing a sugar moiety(compounds 3 and 4) were firstly evaluated for their anti-viral activities against HCMV and VZV by plaque-forming unit(PFU) method.The results showed that 2,3-diaryl-1,3-thiazolidin-4-ones were a new class of potent inhibitors of HCMV,while 1,3-thiazolidin-4-ones bearing a sugar moiety might be a kind of ideal selective herpes simplex virus inhibitors. |
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| Keywords: | Thiazolidin-4-ones HCMV VZV |
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