| 新型抗糖尿病药物曲格列酮的合成 |
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| 引用本文： | 王恩思,段海峰,金磊.新型抗糖尿病药物曲格列酮的合成[J].吉林大学学报(理学版),1999(4):1. |
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| 作者姓名： | 王恩思 段海峰 金磊 |
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| 作者单位： | 吉林大学生命科学学院!长春，130023，长春金赛药业有限责任公司!长春，130012，长春金赛药业有限责任公司!长春，130012 |
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| 摘 要： | 以三甲基氢醌为原料，Meerwin芳基化反应为关键步骤合成新型抗糖尿病药物曲格列酮，总收率达3．3％．关键中间体及最终化合物的结构由元素分析、质谱、核磁共振氢谱及碳谱得到确证．合成中避免使用高温、高压等条件，适合于工业化生产．
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| 关 键 词： | 曲格列酮 抗糖尿病药物 Meerwin芳基化反应 合成 |
| 修稿时间： | :
1999-06 |
Synthesis of a New Antidiabete Medicine 5-[4[(6-hydroxy-
2,5,7,8-tetramethylchroman-2-yl)methoxy]-
benzyl]-2,4-thiazolidinedione |
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| Wang Ensi.Synthesis of a New Antidiabete Medicine 5-[4[(6-hydroxy-
2,5,7,8-tetramethylchroman-2-yl)methoxy]-
benzyl]-2,4-thiazolidinedione[J].Journal of Jilin University: Sci Ed,1999(4):1. |
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| Authors: | Wang Ensi |
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| Abstract: | Trog1ltazune, 5- L4 1 (6-nydroxy-2, 5, 7, 8-tetramethylchroman-2-yl ) methoxy ] -benzyl ]-2, 4-thlazulldinedione was syntheslzed by means of Meerwin arylation as a plvotal step. The total yleld was 3. 3 %. The structures of the key lntermediates and the final product were conflrmed by MS, elementary analysls, 1H NMR and 13C NMR spectra in our experiments. The route detest1ng high presure and high ternperature may be applled to lndustr1al production. |
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| Keywords: | troglitazone hypoglycemic drug Meerwin arylation synthesis |
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