| 5-乙炔基-4-甲基-2-硫甲基嘧啶的合成及表征 |
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| 引用本文： | 光善仪,朱维菊,尹守春,李村,徐洪耀.5-乙炔基-4-甲基-2-硫甲基嘧啶的合成及表征[J].安徽大学学报(自然科学版),2003,27(4):78-82. |
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| 作者姓名： | 光善仪 朱维菊 尹守春 李村 徐洪耀 |
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| 作者单位： | 安徽大学,化学化工学院,安徽,合肥,230039 |
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| 基金项目： | 国家自然科学基金;50073001,90206014; |
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| 摘 要： | 采用酰基化的方法合成了5-乙炔基-4-甲基-2-硫甲基嘧啶,使用傅立叶转换红外光谱、核磁共振和元素分析对分子结构进行表征。讨论和分析了反应的机制,改进了5-(1-氯乙烯)-4-甲基-2-硫甲基嘧啶的合成工艺,获得了71％的产率;使用新制的叔丁醇钾作为催化剂制备5-乙炔基-4-甲基-2-硫甲基嘧啶,在室温条件下获得了68％产率。
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| 关 键 词： | 杂环 乙炔 合成 嘧啶 |
| 文章编号： | 1000-2162(2003)04-0078-05 |
Synthesis and characterization of 5 - ethynyl - 4 - methyl - 2 - sulfomethyl - pyrimidine |
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| GUANG Shan - yi,ZHU Wei -ju,YIN Shou - chun,LI Cun,XU Hong - yao.Synthesis and characterization of 5 - ethynyl - 4 - methyl - 2 - sulfomethyl - pyrimidine[J].Journal of Anhui University(Natural Sciences),2003,27(4):78-82. |
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| Authors: | GUANG Shan - yi ZHU Wei -ju YIN Shou - chun LI Cun XU Hong - yao |
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| Abstract: | 5 - Ethynyl - 4 - methyl - 2 - sulfomethyl - pyrimidine was synthesized using acetyl-ization method and its structure was charateristized by using FT - IR, HNMR and elment analysis. The reaction mechnism was discussed and the synthetic technique of 5 - (1 - chlorovinyl) - 4 - methyl - 2 - sulfomethyl - pyrimidine was improved to attain 71 % yield. 5 - Ethynyl - 4 - methyl - 2 - sulfomethyl- pyrimidine was prepared using potassium tert - butoxide as catalyst to obtain 68% yield at room temperature. |
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| Keywords: | heterocycle acetylene synthesis pyrimidine |
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