| 白柠檬素的合成 |
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| 引用本文： | 庞思平,王琳.白柠檬素的合成[J].北京理工大学学报,2005,25(8):743-744. |
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| 作者姓名： | 庞思平 王琳 |
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| 作者单位： | 北京理工大学,生命科学与技术学院,北京,100081;中国人民解放军63936部队,北京,102202 |
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| 基金项目： | 北京理工大学校科研和教改项目 |
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| 摘 要： | 研究白柠檬素的化学合成工艺.以间苯三酚和丙炔酸乙酯为原料,在无水氯化锌催化下缩合成环得到5,7-二羟基香豆素,收率为97.7%.5,7-二羟基香豆素经甲基化反应得到白柠檬素.研究了影响甲基化反应的各反应条件,确定了以硫酸二甲酯为甲基化试剂,交替滴加30%液碱和硫酸二甲酯的甲基化反应工艺,反应收率为75.5%.对甲基化反应机理进行了讨论.
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| 关 键 词： | 香豆素 甲基化 合成工艺 |
| 文章编号： | 1001-0645（2005）08-0743-03 |
| 收稿时间： | 2004-08-30 |
| 修稿时间： | 2004-08-30 |
Synthesis of Limettin |
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| PANG Si-ping and WANG Lin.Synthesis of Limettin[J].Journal of Beijing Institute of Technology(Natural Science Edition),2005,25(8):743-744. |
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| Authors: | PANG Si-ping and WANG Lin |
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| Institution: | School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China;The Unit No. 63936 of the Chinese People's Liberation Army, Beijing102202, China |
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| Abstract: | The synthesis of limettin is studied. 5,7-dihydroxycoumarin was synthesized through phloroglucin and ethyl propionate by the catalysis of ZnCl_2, with a yield of 97.7%. 5,7-dihydroxycoumarin was reacted with methylation reagents giving limettin. The conditions of methylation reaction were studied in detail and the optimization conditions determined with a yield of 75.7%: dimethyl sulfate was used as the methylation reagent, while dimethyl sulfate and 30% NaOH solution was dropped in alternatively. The mechanism of methylation reaction is discussed. |
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| Keywords: | coumarin methylation synthesis |
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