| 含丝氨酸残基手性肽核酸单体的合成 |
| |
| 引用本文： | 孟庆国,赵风兰,姜乃才.含丝氨酸残基手性肽核酸单体的合成[J].烟台大学学报(自然科学与工程版),2006,19(3):198-201. |
| |
| 作者姓名： | 孟庆国 赵风兰 姜乃才 |
| |
| 作者单位： | 烟台大学,药学院,山东,烟台,264005 |
| |
| 摘 要： | 对文献合成方法进行了改进．以N—Boc氨基酸与自制甲烷磺酸酯反应，制备N—Boc氨基酸丙烯酯，以混合酸酐法实现关键中间体与1-胸腺嘧啶乙酸的缩合，总收率为26．4％，比文献方法提高了12％，成本降低，制备了含丝氨酸残基碱基为胸腺嘧啶的手性肽核酸单体．
|
| 关 键 词： | 肽核酸单体 丝氨酸 合成 甲烷磺酸酯 |
| 文章编号： | 1004-8820（2006）03-0198-04 |
| 收稿时间： | 2005-04-20 |
| 修稿时间： | 2005-04-20 |
Synthesis of Chiral PNA Monomer Containing Serine Residue |
| |
| MENG Qing-guo,ZHAO Feng-lan,JIANG Nai-cai.Synthesis of Chiral PNA Monomer Containing Serine Residue[J].Journal of Yantai University(Natural Science and Engineering edirion),2006,19(3):198-201. |
| |
| Authors: | MENG Qing-guo ZHAO Feng-lan JIANG Nai-cai |
| |
| Institution: | School of Pharmacy, Yantai University, Yantai 264005, China |
| |
| Abstract: | The allyl ester of N-Boc protected serine has been synthesized from allyl methanesulfonate prepared ourself and the condensation of key intermediate and thymin-1-yl-acetic acid have been sucessufully achieved in mixed anhyride in stead of the classic DCC method. Chiral PNA monomer containing serine residue and thymine has been prepared in total yield 26.4%, which is 12% higher than that of the literature method reported, and with low consumption. |
| |
| Keywords: | peptide nucleic acid monomer serine synthesis methanesulfonate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
