| 壳聚糖催化合成香豆素-3-羧酸乙酯 |
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| 引用本文： | 彭望明.壳聚糖催化合成香豆素-3-羧酸乙酯[J].江汉大学学报(自然科学版),2012,40(5):37-40. |
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| 作者姓名： | 彭望明 |
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| 作者单位： | 江汉大学化学与环境工程学院,湖北武汉,430056 |
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| 摘 要： | 以壳聚糖为催化剂,以无水乙醇为溶剂,通过水杨醛与丙二酸二乙酯的Knoevenagel缩合反应合成香豆素-3-羧酸乙酯。对影响香豆素-3-羧酸乙酯产率的因素如反应物物质的量比、反应时间、催化剂用量、溶剂用量、反应温度等进行了研究。结果表明:丙二酸二乙酯0.06 mol、水杨醛0.05 mol、反应时间120 min、壳聚糖3.0 g、无水乙醇10.0 mL、反应温度70℃时,香豆素-3-羧酸乙酯的产率可达87%。催化剂催化效率高,对环境友好,可重复使用。
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| 关 键 词： | 香豆素-3-羧酸乙酯 水杨醛 丙二酸二乙酯 壳聚糖 合成 产率 |
Synthesis of Coumarins -3- ethyl--Earboxylate Catalyzed with Chitosan |
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| PENG Wang-ming.Synthesis of Coumarins -3- ethyl--Earboxylate Catalyzed with Chitosan[J].Journal of Jianghan University:Natural Sciences,2012,40(5):37-40. |
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| Authors: | PENG Wang-ming |
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| Institution: | PENG Wang-ming(School of Chemistry and Environmental Engineering,Jianghan University,Wuhan 430056,Hubei,China) |
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| Abstract: | Coumarin-3- ethyl--carboxylate was synthesized with salicylaldehyde and di- ethylmalonate by using absolute alcohol as solvent and chitosan as catalyst. Some factors that in- flunced the yield of coumarin-3- ethyl--carboxylate were studied. The results showed that the yield of coumarin-3- ethyl--carboxylate was up to 87% when diethylmalonate was 0. 06 mol, sal- icylaldehyde was 0.05 mol, chitosan was 3.0 g, the reaction time was 120 min, and absolute alcohol was 10 mL, the temperature was 70℃. |
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| Keywords: | Coumarin-3- ethyl--carboxylate salicylaldehyde diethylmalonate chitosan synthesis yield |
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