| 新型抗病毒药物喷昔洛韦的合成 |
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| 引用本文： | 王恩思,梁占国,侯长民.新型抗病毒药物喷昔洛韦的合成[J].吉林大学学报(理学版),2000(2):87-89. |
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| 作者姓名： | 王恩思 梁占国 侯长民 |
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| 作者单位： | 1. 吉林大学生命科学学院,长春,136023
2. 长春金赛药业有限责任公司,长春,130012 |
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| 摘 要： | 以2-羟甲基-1，4-丁二醇为原料，采用2-氨基-6-氯嘌呤位置有择烷基化反应合成新型抗病毒药物喷昔洛韦，总收率27％。关键中间体及最终化合物的结构经元素分析、质谱、核磁共振氢谱及碳谱得到确证。合成中避免使用高温、高压及腐蚀性试剂，适于工业化生产。
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| 关 键 词： | 喷昔洛韦 抗病毒药物 烷基化反应 合成 |
| 文章编号： | 0529-0279(2000)02-0087-03 |
| 修稿时间： | 1999-06-28 |
Synthesis of a New Antiviral Medicine Penciclovir |
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| WANG En-Si,LIANG Zhan-Guo,HOU Chang-Min.Synthesis of a New Antiviral Medicine Penciclovir[J].Journal of Jilin University: Sci Ed,2000(2):87-89. |
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| Authors: | WANG En-Si LIANG Zhan-Guo HOU Chang-Min |
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| Institution: | WANG Eh-Si
;(College of Life Science, Jilin University, Changchun,130023);LIANG Zhan-Guo
,HOU Chang-Min
;(Gene Science Pharmaceuticals Co., Ltd., Changchun, 130012) |
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| Abstract: | Penciclovir, 9 4 hydroxy 3 (hydroxymethyl)but 1 yl]guanine was synthesized by means of the regioselective alkylation of 2 amino 6 chloropurine with 5 (2 iodoethyl) 1,3 dioxan as a pivotal step The total yield was 27% The structures of the intermediates and the target molecule were confirmed by MS, elementary analysis, 1H NMR and 13 C NMR spectra in our experiments The route without using highly toxic reagents and high pressure and high temperature may be applied to industrial production. |
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| Keywords: | penciclovir antiviral drug alkylation reaction synthesis |
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