头孢曲松通过抑制Cx43磷酸化参与治疗创伤性颅脑损伤的机制

目的观察头孢曲松(CFX)通过调控与缝隙连接蛋白43(Cx43)表达在治疗创伤性颅脑损伤(TBI)的相关性机制。方法选取100只体重350～450g的4月龄的SD雄性大鼠,采用液压打击仪建立脑损伤模型,具体分组为:①假手术(sham)组、②治疗(TBI+CFX)治疗组、③甘珀酸(CBX)阻断(TBI+CFX+CBX)组、④溶媒(TBI+生理盐水)组及⑤损伤(TBI)组,每组20只。实验时间均设定为TBI后48 h。每组取10只大鼠进行行为学检测和脑组织含水量测定,另10只则获取海马区胶质组织通过蛋白免疫印记法(WB)法测定神经元缝隙连接蛋白40(Cx40)及磷酸化Cx43蛋白(p-Cx43)的变化、采用酶联免疫荧光(ELFA)检测神经元氧化应激因子NADPH氧化酶活性的变化。结果实验结果显示,采用CFX干预组神经损伤严重度评分(NSS)、脑水肿程度、腺嘌呤二核苷酸磷酸(NADPH)氧化酶活性及海马胶质细胞Cx40、p-Cx43表达均溶媒组及损伤组明显下降(P 0.05)。而CBX可明显抑制上述CFX对Cx40、p-Cx43蛋白表达下调及降低NADPH氧化酶的活性的作用(P0.05)。结论 CFX可能通过抑制Cx43蛋白磷酸化和Cx40蛋白异常增多,从而抑制氧化应激反应以达到脑损伤缓解作用。     

The nonleptonic two body B decays involving a light tensor meson in final states

The nonleptonic two body Bu,d,s,c decays involving a light tensor meson in final states are studied in the perturbative QCD approach based on kT factorization. The decay modes with a tensor meson emitted, are prohibited in naive factorization, since the emission diagram with a tensor meson produced from vacuum is vanished. While contributions from the so-called hard scattering emission diagrams and annihilation type diagrams are important and calculable in the perturbative QCD approach. The branching ratios of most decays are in the range of 10-4-10-8, which are bigger by 1 or 2 orders of magnitude than the predictions given by the naive factor- ization, but consistent with the predictions from the QCD factorization and the recent experimental measurements. We also give the predictions for the direct CP asymmetries, some of which are large enough for the future experiments to measure. We also find that, even with a small mixing angle, the mixing between f2 and f′2 can bring remarkable changes to both branching ratios and the direct CP asymmetries for some decays involving f2（′） mesons. For decays with a vector meson and a tensor meson in final states, we predict a large percentage of transverse polarization contributions due to the contributions of the orbital angular momentum of the tensor mesons.     

HIs classification in HCR model for operator reliability study of nuclear power plants

The human cognition reliability model is used to study time-related human response interaction (HI). The classification of HI types is an important base. At present, the two types of HIS classification (i.e. SRK classification and CP classification) are based on subjective or objective characteristics respectively by which some phenomena can be hardly explained. Since the types were limited, they could not meet the requirements. The integrate approach of HIs classification is compatible with the original methods, and HIs are classified according to subjective and objective characteristics. The integrate approach contains more detailed types and has higher precision. It is more advantageous and convenient for the classification of HIs. The integrate approach has been used in the study of operator reliability for nuclear power plants in China. The results were satisfactory, and by which the integrate approach was verified.     

客运专线CPⅢ控制网施工技术研究

为满足行车速度快、乘坐舒适度高的要求,客运专线列车在运营时对轨道的平直度提出了较高的要求。CPⅢ控制网是列车运营维护的基准,具有重要的作用。结合新建铁路长春至吉林城际客运专线,对CPⅢ控制网施工流程和测量方式进行了详细的分析。     

大鼠脑损伤后海马GAP-43 mRNA水平的变化

以DIG（Digoxigenin）标记的GAP-43 cDNA片段为探针,使用原位杂交方法,检测了大鼠皮层硬性脑挫伤后GAP-43 mRNA水平的变化。结果表明：海马CA3、CA1和DG区的GAP-43 mRNA水平在损伤后48h明显升高,其中CA3区变化最甚,而且伤侧比对侧显著。1周和2周后表达仍维持较高水平,但不如48h的高,这显示表达的峰值在1周之内。上述结果为研究脑损伤后生理及机能代偿的修复机制提供了有意义的信息。     

OFDM系统中干扰消除技术的分析

正交频分复用（OFDM）技术已被越来越多的人所关注,并且在IEEE802．11无线局域网中得到实际应用．在OFDM系统中为了消除符号间干扰（ISI）和子载波间干扰（ICI）,一般要采用加入循环前缀（CP）的技术．从信道对信号作用方面分析了循环前缀技术消除干扰的过程,并给出了仿真结果．结果表明,循环前缀的加入可以有效地消除符号间干扰（ISI）和子载波间干扰（ICI）．     

基于FB41与FB43的夹套锅炉温度控制系统设计

在两门子FB41与FB43软模块平台下,设计了夹套锅炉温度控制系统.首先,对系统的硬件部分进行了设计;接着对FB41与FB43模块的算法进行了介绍并详细阐述了 FB41与FB43组合在一起实现控制的过程,在此基础上,对程序进行了设计;最后通过改变给定值与干扰信号对系统进行了验证.结果表明:系统的输出能快速准确地跟踪给定信号,达到了良好的控制效果.     

不同恶化程度胃癌细胞系的细胞间隙连接通讯功能及Cx43表达的差异

以人正常胃黏膜上皮细胞系GES-1和不同恶化程度的人胃癌细胞系(低恶化AGS细胞系、中恶化SGC-7901细胞系、高恶化BGC-823细胞系)为研究对象,采用激光共聚焦显微镜的荧光漂白恢复技术及划痕标记荧光染料示踪技术研究不同恶化程度的胃癌细胞系细胞间隙连接通讯(Gap junctional intercellular communication,GJIC)功能的差异;采用荧光定量PCR技术和间接免疫荧光技术检测间隙连接蛋白(Connexin43,Cx43)基因在mRNA和蛋白水平的表达差异,探求其与胃癌恶性程度的相关性.结果表明,在正常胃细胞系和低、中及高恶化胃腺癌细胞系中,细胞间的GJIC功能随着恶性程度的升高而减弱(AGS、SGC-7901)或消失(BGC-823),且Cx43蛋白及mRNA的表达量随着恶性程度的升高而下调(AGS、SGC-7901)或缺失(BGC-823).这提示胃癌恶性程度与胃癌细胞的GJIC功能显著相关(P<0.05),GJIC在胃癌发生中起重要作用.     

DTMF发送接收器MT8888在微波一点多址通信中的应用

文中重点介绍了一种ＤＴＭＦ收发器ＭＴ８８８８的性能及其在微波一点多址通信中的应用。该芯片集接收、发送ＤＴＭＦ信号、检测呼叫过程于一身，可编程控制，广泛应用于程控交换机、无线通信设备、移动通信等系统中     

定压容量和定体热容量的进一步探讨

讨论了与CP和Cv有关的三个问题:(1)CP和CV是物质的性质;(2)dE=CVdT只适用于内能E仅与温度T有关的系统;(3)理想气体的(CP-CV)值不受分子内部运动的影响。