Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

利用遗传算法及Gastreich提出的经验势函数,研究了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇的可能稳定结构,对能量较低的异构体在HF/STO-3G水平进行优化,得到了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇稳定结构单环及线状结构,并进一步分析了单环的结构特征及相对稳定性。     

日本人的“ラち”、“そと”意识与日语的时态转换

从日本人的“ラち”、“そと”意识角度出发，通过对川端康成、志贺直哉的几部小说进行分析统计，探讨日语在描写过去的事件中，插入“内时态‘る’形”的条件和原因。分析发现当作者为了使作品更生动，或是作者与作品中人物产生“同感”时，或是表达作者的主观思想、评论时，往往发生时态的转换。     

基于集成平台的CAPP和PPC集成系统

按照ＣＡＰＰ和ＰＰＣ的多级并行分布式集成体系结构建立ＣＡＰＰ和ＰＰＣ集成系统ＳＩＰＰ．该系统采用五层集成结构,用一级实现所有层次的集成功能,用逻辑分布模拟物理分布,系统可以在一台或多台计算机上实现．该系统基于统一的集成平台,易于达成巨量中间过程决策数据的共享,确保了功能集成的实现,同时也实现了与ＣＡＤ、资源建模等其他系统或功能的集成．系统可用来对ＣＡＰＰ和ＰＰＣ的整个集成过程进行仿真,生成整体优化的工艺计划和生产计划．     

EDA软件在电路设计中的应用

在EDA软件的基础上，介绍了仿真功能在数字逻辑电路设计中的应用。佐证了由传统实验教学向现代化创新性教学的重要性。并进行了三个数字电路仿真设计分析举例。     

异结构混沌系统同步控制的仿真研究

考虑到目前混沌同步问题主要研究结构相似的混沌系统之间同步控制的现状,本文提出运用非线性控制定律实现两个异结构混沌系统的同步控制,实现了新的混沌系统和一类统一混沌系统的同步控制.并运用非线性控制定律设计控制函数,得到了控制系数的稳定范围.采用Matlab进行数字仿真表明该同步控制方法的可行性.又利用EWB设计模拟电路,结果与Matlab的仿真结果吻合,更进一步证明了该同步方法的有效性.     

模拟电容与电感及其仿真分析

模拟电容与模拟电感在集成电路中得到了广泛的应用．本文引入模拟电容与模拟电感模型，对两模型电路作了详细的时频分析和EWB(Electronics Workbench)软件仿真分析．以五阶Butterworth滤波器电路为例，通过对滤波器电路及其仿真电感替换电路的仿真对比分析，进一步验证了仿真电感模型的电感特性．     

中国载人交会对接技术的设计与实现

中国在载人航天工程第二步第一阶段任务中,自主研制了天宫一号目标飞行器和神舟八号、神舟九号、神舟十号载人飞船,通过3次在轨飞行任务完成了8次交会、6次对接,覆盖了自动和手动等多种交会对接模式,突破并掌握了交会对接技术.从交会对接系统、交会轨道、交会测量和控制、信息传输、对接与分离、飞行方案,以及试验验证等方面对中国载人交会对接设计的技术特点、所采用的创新技术方法和解决的技术难题进行了介绍,在飞行验证的基础上分析了工程任务取得的成果,与国际水平进行了综合比较,对中国载人交会对接技术的设计和研制情况进行了总结.     

清中后期社会历史文化心态的展现——以小说《荡寇志》为例

《荡寇志》是清中后期保守士人面对西潮涌入、传统文化失落的集体性情感反应的产物,小说作者俞万春以捍卫中国传统文化的基本价值为己任,担负起了文化卫道的使命。但残酷的现实却撕碎了他加强君权、帝制,肃清内乱来重振国威的卫道美梦,小说《荡寇志》便展示了这一特定历史时期各种社会变革思潮下的社会历史文化心态。     

Description of rotational properties of the superheavy nucleus ^256,258,260Rf by projected shell model

Band structure of the Z = 104 nucleus 256Rf has been a recent research focus in nuclear physics. We performed projected shell model calculations for this and some other neighboring Rf isotopes. Specifically, we studied rotational properties of these nuclei and showed that variations in dynamic moment of inertia were sensitive to single-particle structures, which may be useful information for locating the anticipated island of stability. Electromagnetic transition properties were also calculated, and measurable quantities were predicted for further experimental test.