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G. Venturini M. Giliberti R. A. Scarcella 《Cellular and molecular life sciences : CMLS》1988,44(6):500-501
Summary Pharmacological observations on the glutathione-induced feeding response in Hydra demonstrate that phorbol esters, calcium ionophore A 23187 and lithium ions significantly enhance and protract glutathione action, whereas polymixin B induces a dramatic shortening of the feeding response. An involvement of membrane phosphatidylinositol breakdown in the control of the feeding response is suggested. 相似文献
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Martelli AM Bortul R Tabellini G Bareggi R Manzoli L Narducci P Cocco L 《Cellular and molecular life sciences : CMLS》2002,59(7):1129-1137
Several independent groups have shown that lipid-dependent signal transduction systems operate in the nucleus and that they
are regulated independently from their membrane and cytosolic counterparts. A sizable body of evidence suggests that nuclear
lipid signaling controls critical biological functions such as cell proliferation and differentiation. Diacylglycerol is a
fundamental lipid second messenger which is produced in the nucleus. The levels of nuclear diacylglycerol fluctuate during
the cell cycle progression, suggesting that such a molecule has important regulatory roles. Most likely, nuclear diacylglycerol
serves as a chemoattractant for some isoforms of protein kinase C that migrate to the nucleus in response to a variety of
agonists. The nucleus also contains diacylglycerol kinases, i.e. the enzymes that, by converting diacylglycerol into phosphatidic
acid, terminate diacylglycerol-dependent events. A number of diacylglycerol kinases encoded by separate genes are present
in the mammalian genome. This review aims at highlighting the different isotypes of diacylglycerol kinases identified at the
nuclear level as well as at discussing their potential function and regulation.
Received 4 December 2001; received after revision 28 January 2002; accepted 31 January 2002 相似文献
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Implication of phosphoinositide phosphatases in genetic diseases: the case of myotubularin 总被引:1,自引:0,他引:1
Tronchère H Buj-Bello A Mandel JL Payrastre B 《Cellular and molecular life sciences : CMLS》2003,60(10):2084-2099
Phosphoinositides play a central role in the control of major eukaryotic cell signaling mechanisms. Accordingly, the list of phosphoinositide-metabolizing enzymes implicated in human diseases has considerably increased these last years. Here we will focus on myotubularin, the protein mutated in the X-linked myotubular myopathy (XLMTM) and the founding member of a family of 13 related proteins. Recent data demonstrate that myotubularin and several other members of the family are potent lipid phosphatases showing a marked specificity for phosphatidylinositol 3-phosphate [PtdIns(3)P]. This finding has raised considerable interest as PtdIns(3)P is implicated in vesicular trafficking and sorting through its binding to specific protein domains. The structure of myotubularin, the molecular mechanisms of its function and its implication in the etiology of XLMTM will be discussed, as well as the potential function and role of the other members of the family.Received 14 February 2003; received after revision 10 April 2003; accepted 14 April 2003 相似文献
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