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Nabeshima Y 《Cellular and molecular life sciences : CMLS》2008,65(20):3218-3230
The traditional view of calcium homeostasis is that it is maintained by two essential reactions. First, changes in extracellular
Ca2+ are sensed in several distinct cell types, stimulating the secretion of parathyroid hormone (PTH), 1,25(OH)2 D and calcitonin in response to the body’s requirement. Second, these calcitropic hormones then act on the calcium-translocating
cells of the kidney, bone, and intestine to restore calcium balance. Recent progress indicates that α-Klotho and fibroblast
growth factor (FGF) 23 are key players that integrate the multi-step regulatory system of calcium homeostasis that rapidly
adjusts the extracellular calcium concentration and continuously maintains its concentration within a narrow physiological
range. α-Klotho and FGF23 are also found to be major players in the regulatory system of phosphate homeostasis. Here, the
demonstration of the molecular functions of α-Klotho and FGF23 has recently given new insight into the field of calcium and
phosphate homeostasis.
Received 3 April 2008; received after revision 23 May 2008; accepted 5 June 2008 相似文献
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Closely allied spider species Cheiracanthium japonicum and Cheiracanthium lascivum make a closed breeding nest for egg laying and parental care. The nest provides the internal climatic stability required for suitable development of eggs and the physical durability required for protection against intruders. Although the breeding nests of these two spiders are quite similar in structure and appearance, their climatic stability and physical durability seem to be empirically different. Such physical features of the nests of these two spiders were compared based on a balance between the inner and outer air temperature and humidity of the nest as well as on the amount and size of spider silks lining the nest. In addition, the female’s relative energy allocation to egg production versus nest construction was examined based on the number or weight of eggs versus the climatic stability and physical durability of the nest. According to the results, the stability of temperature and humidity was maintained better in the breeding nest of C. japonicum than in that of C. lascivum. Furthermore, the nest of C. japonicum was more strongly constructed, with a greater volume and size of silks, than that of C. lascivum. On the other hand, the number or weight of eggs in relation to the female’s body weight in C. japonicum was smaller than that in C. lascivum. These results suggested that the reproductive effort towards nest construction for the purpose of egg and juvenile care in C. japonicum was larger than that in C. lascivum. In contrast, the effort towards egg production in C. japonicum was smaller than that in C. lascivum. Consequently, it is likely that the structural differences in breeding nests between these two spiders are responsible for the discrepancies in the female’s relative energy allocation to nest construction. 相似文献
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