可降解纳米氧化钇空心球载药体系的体外抗肿瘤效应

纳米氧化钇空心球在生物医学领域具有广泛的应用.以酚醛树脂微球为模板,合成出了尺寸均一、分散性好的纳米Y₂O₃空心球(HYNPs).它不仅在体外表现出显著的酸性降解行为,而且负载抗肿瘤药物阿霉素(DOX)后,载药体系HYNPs-DOX也表现出明显的pH响应药物释放特点.pH为5.0时,72 h的药物释放可达到70.46%;而pH为 7.4时,72 h的药物释放仅25.04%.进一步通过激光共聚焦显微镜监测载药体系在细胞内的DOX释放,发现随着时间的延长,细胞内DOX的荧光逐渐增加,表明DOX在细胞内释放量的增加.体外抗肿瘤细胞毒性结果显示,HYNPs对肿瘤细胞MCF-7和MDA-MB-231的活性没有影响,而HYNPs-DOX则表现出较高的体外抗肿瘤效应,与游离DOX相当.可见,该材料作为抗肿瘤药物载体具有潜在的应用价值.     

长治县水资源开发利用现状及存在的问题

通过对长治县水资源开发利用现状的研究和分析,总结了水资源开发利用中存在的问题,提出了相关的建议,为当地合理开发利用水资源提供参考。     

Regional Prediction of Impending Debris Flow Based on Doppler Weather Radar

Debris flow prediction is one of the important means to reduce the loss caused by debris flow. This paper built a regional prediction model of impending debris flow based on regional environmental background （including topography, geology, land use, and etc.）, rainfall and debris flow data. A system of regional prediction of impending debris flow was set up on ArcGIS 9.0 platform according to the model. The system used forecast precipitation data of Doppler weather radar and observational precipitation data as its input data. It could provide a prediction about the possibility of debris flow one to three hours before it happened, and was put into use in Liangshan Meteorological Observatory in Sichuan province in the monsoon of 2006.