飞秒光纤光源的波分解复用 复用实验

为研究飞秒光源作为链路初始光源的可行性，使用阵列波导光栅（AWG）对265 fs光纤光源进行波分解复用 复用实验。实验光源波长为1 52765～1 56505 nm，通道数为48，通道间隔为080 nm。研究发现:在分波实验中，飞秒光纤光源经过AWG后，扫描谱线3 dB带宽为064 nm ，相邻通道串扰为2726 dB，比连续光源增大502 dB；在合波实验中，观察到AWG多端口端对宽带光源的波长选择作用，验证了AWG的色散特性，发现多光束的输出谱线总体轮廓未出现太大变形；在波分解复用 复用实验中，谱线最大损耗为251 dB，输出谱线轮廓和初始光谱基本一致，信号在传输过程中未出现明显失真，证明飞秒光源作为链路初始光源的可行性。     

基于科技查新数据的用户拓展及其关联聚类

科技查新用户数据是查新业务积累的真实而宝贵的资源,其充分利用不仅是查新业务管理的需要,可提升查新服务水平,同时还能用于挖掘更多的情报价值.调研发现,当前对科技查新用户数据的挖掘利用仍以基础性的业务管理分析为主,而增值情报价值的挖掘较少.为拓展成都文献情报中心科技查新客户群体和增值服务范围,做大做强查新业务,立足成都中心查新服务实践,依托于积累查新用户及其服务记录,在挖掘发现潜在服务对象的基础上,通过多维用户关联聚类,探讨了后期信息情报服务的精准营销与推送,分析了基于用户聚类的服务推荐存在的不足,展望了挖掘更多需求信息的推荐路径.     

QT工艺对一种B-Nb低碳贝氏体钢 组织及强韧性的影响

通过室温拉伸、摆锤冲击、光学及扫描电镜研究了QT(淬火+回火)工艺对实验钢晶界比例、晶粒尺寸、碳化物析出情况及强韧性的影响，并对其变体的分布及组合方式进行了分析.结果表明:随着回火温度的升高，实验钢强度逐渐降低，塑性逐渐提高;450T和500T钢断口为准解理型断裂，贝氏体板条间析出的碳化物及较低比例的大角度晶界使得冲击韧性较差;而600T和650T钢断口为韧窝断裂，组织中大角度晶界的比例增加，有效地阻碍了裂纹的扩展.变体分析表明，450T钢变体组合方式介于Bain group和CP(close packed)group之间，而600T钢变体之间呈现较明显的CP组合方式，同一CP group内的变体取向差较大，偏折了裂纹传播路径，提高了低温韧性.     

西安市夜间旅游公共服务体系构建与质量评价

旅游公共服务是随着旅游业诞生而产生的,旅游公共服务水平作为衡量地区旅游业发展质量和社会经济发展水平的重要指标之一,近年来受到国内外学者的广泛关注.夜间经济的发展与旅游公共服务水平息息相关,如何实现旅游公共服务设施由白昼场景向昼夜双场景的转换,从而实现夜间经济高质量发展必将成为学术界研究的热点.本文以夜间经济十强城市——西安市为研究对象,通过分发调查问卷收集相关信息数据,并运用SPSS进行数据分析、建立模型.聚焦夜间旅游公共服务质量的影响因子,发现西安市各项夜间旅游公共服务水平与夜间旅游公共服务总体水平成正相关,均逐年提升,其中夜间旅游公共交通服务、夜间旅游公共安全保障服务综合水平较高,对夜间旅游公共服务质量产生显著影响,而夜间旅游公共信息咨询服务水平相对较低,进而为西安市及相同案例区旅游公共服务体系优化提供针对性对策.     

The TET enzymes

During the past decade, we have learnt that the most common DNA modification, 5-methylcytosine (5mC), playing crucial roles in development and disease, is not stable but can be actively reversed to its unmodified form via enzymatic catalysis involving the TET enzymes. These ground-breaking discoveries have been achieved thanks to technological advances in the detection of the oxidized forms of 5mC and to the boldness of individual scientists. The TET enzymes require molecular oxygen for their catalysis, making them important targets for hypoxia research. They also require special cofactors which enable additional levels of regulation. Moreover, mutations and other genetic alterations in TETs are found, especially in myeloid malignances. This review focuses on the kinetic and inhibitory properties of the TET enzymes and the role of TETs in cellular differentiation and transformation and in cancer.     

Current knowledge on exosome biogenesis and release

Exosomes are nanosized membrane vesicles released by fusion of an organelle of the endocytic pathway, the multivesicular body, with the plasma membrane. This process was discovered more than 30 years ago, and during these years, exosomes have gone from being considered as cellular waste disposal to mediate a novel mechanism of cell-to-cell communication. The exponential interest in exosomes experienced during recent years is due to their important roles in health and disease and to their potential clinical application in therapy and diagnosis. However, important aspects of the biology of exosomes remain unknown. To explore the use of exosomes in the clinic, it is essential that the basic molecular mechanisms behind the transport and function of these vesicles are better understood. We have here summarized what is presently known about how exosomes are formed and released by cells. Moreover, other cellular processes related to exosome biogenesis and release, such as autophagy and lysosomal exocytosis are presented. Finally, methodological aspects related to exosome release studies are discussed.     

Study on the Centralization Strategy of the Blood Allocation Among Different Departments within a Hospital

By far, the researches on how to distribute blood products among different departments in hospital have not been further studied, though the problem of blood shortage and wastage that caused by improper blood allocation is severe, which may endanger patient’s lives and impose considerable costs on hospitals. In order to solve this problem, this paper mainly studies on how to distribute the blood items among different departments within a hospital and investigates the allocation approach with the novel management method by centralizing the inventory of several different departments. By integrating the blood inventory requirements of some departments, the hospital could reduce the rate of blood shortage and wastage effectively, release the pressure of the occupancy of resources and reduce the bullwhip effect of blood products. This paper illustrates the centralization principle in hospital and formulates the mixed integer programming model to work out the optimal allocation network scheme and the optimal inventory setting for every department. And the results of the numerical example demonstrate that this centralization method could considerably reduce blood shortage and wastage in hospital by about 72% and 90% respectively. Furthermore, it could decrease the total cost by about 108,540 RMB a month on blood supply chain management in the hospital and improve the effect of some certain surgeries by transfusing the fresh blood to patients.