排序方式: 共有18条查询结果,搜索用时 15 毫秒
1.
F. A. Vega M. Fernandez P. G. Casado M. Esteruelas 《Cellular and molecular life sciences : CMLS》1969,25(4):447-448
Resumen Se describe un método de filtración sencilla a través de poliamidas, con el cual se han conseguido los mejores resultados en la separación de los glucósidos cardiotónicos y flavonoides de las preparaciones de escila. 相似文献
2.
Desnues C Rodriguez-Brito B Rayhawk S Kelley S Tran T Haynes M Liu H Furlan M Wegley L Chau B Ruan Y Hall D Angly FE Edwards RA Li L Thurber RV Reid RP Siefert J Souza V Valentine DL Swan BK Breitbart M Rohwer F 《Nature》2008,452(7185):340-343
Viruses, and more particularly phages (viruses that infect bacteria), represent one of the most abundant living entities in aquatic and terrestrial environments. The biogeography of phages has only recently been investigated and so far reveals a cosmopolitan distribution of phage genetic material (or genotypes). Here we address this cosmopolitan distribution through the analysis of phage communities in modern microbialites, the living representatives of one of the most ancient life forms on Earth. On the basis of a comparative metagenomic analysis of viral communities associated with marine (Highborne Cay, Bahamas) and freshwater (Pozas Azules II and Rio Mesquites, Mexico) microbialites, we show that some phage genotypes are geographically restricted. The high percentage of unknown sequences recovered from the three metagenomes (>97%), the low percentage similarities with sequences from other environmental viral (n = 42) and microbial (n = 36) metagenomes, and the absence of viral genotypes shared among microbialites indicate that viruses are genetically unique in these environments. Identifiable sequences in the Highborne Cay metagenome were dominated by single-stranded DNA microphages that were not detected in any other samples examined, including sea water, fresh water, sediment, terrestrial, extreme, metazoan-associated and marine microbial mats. Finally, a marine signature was present in the phage community of the Pozas Azules II microbialites, even though this environment has not been in contact with the ocean for tens of millions of years. Taken together, these results prove that viruses in modern microbialites display biogeographical variability and suggest that they may be derived from an ancient community. 相似文献
3.
F. E. Vega P. Barbosa H. L. Kuo-Sell D. B. Fisher T. C. Nelsen 《Cellular and molecular life sciences : CMLS》1995,51(3):293-299
Insect-transmitted plant pathogens can have positive, negative or no effects on the vector insect. Effects could be direct (caused by the pathogen) or indirect (mediated by changes in the plant). Pathogen effects on non-vector insects are less well known.Peregrinus maidis (Ashmead) (Homoptera: Delphacidae), an insect that is not a vector of the corn stunt spiroplasma (CSS), weighed less 15 days after feeding on CSS-infected corn plants relative to insects feeding on healthy corn plants. Fecundity of non-vector insects that were removed from diseased plants was higher than for insects coming from healthy plants. ForDalbulus maidis (DeLong & Wolcott) (Homoptera: Cicadellidae), an insect that transmits CSS, there were no differences in weight, longevity, eggs per day, weekly or total fecundity after feeding on healthy or on CSS-infected corn plants. Significant differences in some phloem amino acids were detected between healthy and CSS-infected plants. Infected plants also showed an increased phloem acidity as disease symptoms progressed. Feeding on CSS-infected corn plants by an insect that does not vector the pathogen infecting the plant can have favorable consequences as evidenced by an increased fecundity.Scientific aritcle no. 8819, contribution no. A-6605 of the Maryland Agricultural Experiment Station. 相似文献
4.
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells 总被引:45,自引:0,他引:45
5.
Vega H Waisfisz Q Gordillo M Sakai N Yanagihara I Yamada M van Gosliga D Kayserili H Xu C Ozono K Jabs EW Inui K Joenje H 《Nature genetics》2005,37(5):468-470
Roberts syndrome is an autosomal recessive disorder characterized by craniofacial anomalies, tetraphocomelia and loss of cohesion at heterochromatic regions of centromeres and the Y chromosome. We identified mutations in a new human gene, ESCO2, associated with Roberts syndrome in 15 kindreds. The ESCO2 protein product is a member of a conserved protein family that is required for the establishment of sister chromatid cohesion during S phase and has putative acetyltransferase activity. 相似文献
6.
Marine Baptissart Aurelie Vega Emmanuelle Martinot Silvère Baron Jean-Marc A. Lobaccaro David H. Volle 《Cellular and molecular life sciences : CMLS》2013,70(23):4511-4526
Bile acids are cholesterol metabolites that have been extensively studied in recent decades. In addition to having ancestral roles in digestion and fat solubilization, bile acids have recently been described as signaling molecules involved in many physiological functions, such as glucose and energy metabolisms. These signaling pathways involve the activation of the nuclear receptor farnesoid X receptor (FXRα) or of the G protein-coupled receptor TGR5. In this review, we will focus on the emerging role of FXRα, suggesting important functions for the receptor in steroid metabolism. It has been described that FXRα is expressed in the adrenal glands and testes, where it seems to control steroid production. FXRα also participates in steroid catabolism in the liver and interferes with the steroid signaling pathways in target tissues via crosstalk with steroid receptors. In this review, we discuss the potential impacts of bile acid (BA), through its interactions with steroid metabolism, on glucose metabolism, sexual function, and prostate and breast cancers. Although several of the published reports rely on in vitro studies, they highlight the need to understand the interactions that may affect health. This effect is important because BA levels are increased in several pathophysiological conditions related to liver injuries. Additionally, BA receptors are targeted clinically using therapeutics to treat liver diseases, diabetes, and cancers. 相似文献
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8.
Diego-García E Abdel-Mottaleb Y Schwartz EF de la Vega RC Tytgat J Possani LD 《Cellular and molecular life sciences : CMLS》2008,65(1):187-200
Among the scorpion venom components whose function are poorly known or even show contrasting pharmacological results are those
called “orphan peptides”. The most widely distributed are named β-KTx or scorpine-like peptides. They contain three disulfide
bridges with two recognizable domains: a freely moving N-terminal amino acid sequence and a tightly folded C-terminal region
with a cysteine-stabilized α/β (CS-αβ) motif. Four such peptides and three cloned genes are reported here. They were assayed
for their cytolytic, antimicrobial and K
+ channel-blocking activities. Two main characteristics were found: the existence of an unusual structural and functional diversity,
whereby the full-length peptide can lyse cells or kill microorganisms, and a C-terminal domain containing the CS-αβ motif
that can block K
+ channels. Furthermore, sequence analyses and phylogenetic reconstructions are used to discuss the evolution of this type
of peptide and to highlight the versatility of the CS-αβ structures.
Received 13 August 2007; received after revision 30 October 2007; accepted 2 November 2007 相似文献
9.
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 总被引:16,自引:0,他引:16
Hampe J Franke A Rosenstiel P Till A Teuber M Huse K Albrecht M Mayr G De La Vega FM Briggs J Günther S Prescott NJ Onnie CM Häsler R Sipos B Fölsch UR Lengauer T Platzer M Mathew CG Krawczak M Schreiber S 《Nature genetics》2007,39(2):207-211
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease. 相似文献
10.