A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Authors:	Hampe Jochen Franke Andre Rosenstiel Philip Till Andreas Teuber Markus Huse Klaus Albrecht Mario Mayr Gabriele De La Vega Francisco M Briggs Jason Günther Simone Prescott Natalie J Onnie Clive M Häsler Robert Sipos Bence Fölsch Ulrich R Lengauer Thomas Platzer Matthias Mathew Christopher G Krawczak Michael Schreiber Stefan

Institution:	Institute for Clinical Molecular Biology, Christian-Albrechts University Kiel, University Hospital Schleswig-Holstein, 24105 Kiel, Germany. jhampe@1med.uni-kiel.de

Abstract:	We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease.

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