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TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation 总被引:1,自引:0,他引:1
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Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response 总被引:15,自引:0,他引:15
Garlanda C Hirsch E Bozza S Salustri A De Acetis M Nota R Maccagno A Riva F Bottazzi B Peri G Doni A Vago L Botto M De Santis R Carminati P Siracusa G Altruda F Vecchi A Romani L Mantovani A 《Nature》2002,420(6912):182-186
Pentraxins are a superfamily of conserved proteins that are characterized by a cyclic multimeric structure. The classical short pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP), are acute-phase proteins produced in the liver in response to inflammatory mediators. Short pentraxins regulate innate resistance to microbes and the scavenging of cellular debris and extracellular matrix components. In contrast, long pentraxins have an unrelated, long amino-terminal domain coupled to the carboxy-terminal pentraxin domain, and differ, with respect to short pentraxins, in their gene organization, chromosomal localization, cellular source, and in their stimuli-inducing and ligand-recognition ability. To investigate the in vivo function of the long pentraxin PTX3, we generated mice deficient in Ptx3 by homologous recombination. Ptx3-null mice were susceptible to invasive pulmonary aspergillosis. Ptx3 binds selected microbial agents, including conidia of Aspergillus fumigatus, and we found that susceptibility of Ptx3-null mice was associated with defective recognition of conidia by alveolar macrophages and dendritic cells, as well as inappropriate induction of an adaptive type 2 response. Thus, the long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus. 相似文献
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Herron BJ Liddell RA Parker A Grant S Kinne J Fisher JK Siracusa LD 《Nature genetics》2005,37(11):1210-1212
Stratifin (Sfn, also called 14-3-3sigma) is highly expressed in differentiating epidermis and mediates cell cycle arrest. Sfn is repressed in cancer, but its function during development is uncharacterized. We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning. Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice. 相似文献
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