全文获取类型
收费全文 | 135篇 |
免费 | 2篇 |
专业分类
系统科学 | 1篇 |
现状及发展 | 44篇 |
研究方法 | 33篇 |
综合类 | 52篇 |
自然研究 | 7篇 |
出版年
2021年 | 1篇 |
2018年 | 4篇 |
2017年 | 6篇 |
2016年 | 7篇 |
2015年 | 6篇 |
2014年 | 3篇 |
2013年 | 1篇 |
2012年 | 10篇 |
2011年 | 11篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 15篇 |
2007年 | 10篇 |
2006年 | 10篇 |
2005年 | 8篇 |
2004年 | 3篇 |
2003年 | 6篇 |
2002年 | 6篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1992年 | 2篇 |
1986年 | 1篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1972年 | 1篇 |
1971年 | 3篇 |
1970年 | 1篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1965年 | 3篇 |
1961年 | 1篇 |
1956年 | 1篇 |
排序方式: 共有137条查询结果,搜索用时 20 毫秒
1.
Russell L. Burke Beverly Clendening Alexandra Kanonik 《Journal of Natural History》2018,52(25-26):1723-1732
Clutch size (CS) is a well-studied life history characteristic, and optimal egg size theory predicts that CS should correlate positively with reproductive investment. Turtles are good subjects for studies of reproductive strategies because few turtle species exhibit parental care; therefore quantifying their short-term reproductive investment is mostly limited to measuring egg size and number. Clutch size is usually reported as an average value for each turtle population, and where CS variation is noted, it is usually attributable to variation in adult body size. In two long-term studies of ecologically dissimilar species we detected a dramatic increase in CS in a common snapping turtle (Chelydra serpentina) population and in a diamondback terrapin (Malaclemys terrapin) population. It is unknown whether these changes are due to either variation in adult body size or resource availability; but the temporal patterns we observed have apparently never been reported previously. These trends remain unexplained and should be explored further. 相似文献
2.
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 总被引:14,自引:0,他引:14
van Heel DA Franke L Hunt KA Gwilliam R Zhernakova A Inouye M Wapenaar MC Barnardo MC Bethel G Holmes GK Feighery C Jewell D Kelleher D Kumar P Travis S Walters JR Sanders DS Howdle P Swift J Playford RJ McLaren WM Mearin ML Mulder CJ McManus R McGinnis R Cardon LR Deloukas P Wijmenga C 《Nature genetics》2007,39(7):827-829
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. 相似文献
3.
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants 总被引:2,自引:0,他引:2
Wellcome Trust Case Control Consortium;Australo-Anglo-American Spondylitis Consortium 《Nature genetics》2007,39(11):1329-1337
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. 相似文献
4.
Alexandra Sauer 《Systemic Practice and Action Research》2008,21(6):497-515
The participation of non-state actors in implementation processes is often understood as a means to increase compliance efficiency.
But the implementation of spatial policies frequently focuses on pre-established goals, processes and instruments and thus
renders difficult open discourse and shared decision-making. This paper introduces conflict pattern analysis (CPA) as a tool
that supports the analysis of the actual actor constellation in order to define efficient approaches that avoid common problems
of participatory processes. CPA is a semi-formalised method that helps to identify key-actors, their relations and interaction
amongst each other as well as their core beliefs, interests and resources. It aggregates this information to interaction patterns
that can be compared, classified and linked to different participatory methods on a theoretically informed basis. Particularly
on the local and regional level, this could be the first step for successful (participatory) implementation strategies. 相似文献
5.
6.
7.
de Oliveira JC 《Studies in history and philosophy of science》2012,43(1):115-121
In this paper I identify a tension between the two sets of works by Kuhn regarding the genesis of the "new historiography of science". In the first, it could be said that the change from the traditional to the new historiography is strictly endogenous (referring to internal causes or reasons). In the second, the change is predominantly exogenous. To address this question, I draw on a text that is considered to be less important among Kuhn's works, but which, as shall be argued, allows some contact between Kuhn's two approaches via Koyré. I seek to point out and differentiate the roles of Koyré and Kuhn--from Kuhn's point of view--in the development of the historiography of science and, as a complement, present some reflections regarding the justification of the new historiography. 相似文献
8.
J. A. Houle Alexandra Piwonska O. A. Carretero 《Cellular and molecular life sciences : CMLS》1972,28(3):279-280
Résumé La liaison de l'angiotensine par les protéines plasmatiques est démontrée par dialyse équilibrée. L'angiotensine radioactive liée ne put être déplacée par l'angiotensine non radioactive, ce qui diminue la signification physiologique de cette liaison.
Supported in part by the Michigan Heart Association. 相似文献
Supported in part by the Michigan Heart Association. 相似文献
9.
The knockout mouse project 总被引:1,自引:0,他引:1
Austin CP Battey JF Bradley A Bucan M Capecchi M Collins FS Dove WF Duyk G Dymecki S Eppig JT Grieder FB Heintz N Hicks G Insel TR Joyner A Koller BH Lloyd KC Magnuson T Moore MW Nagy A Pollock JD Roses AD Sands AT Seed B Skarnes WC Snoddy J Soriano P Stewart DJ Stewart F Stillman B Varmus H Varticovski L Verma IM Vogt TF von Melchner H Witkowski J Woychik RP Wurst W Yancopoulos GD Young SG Zambrowicz B 《Nature genetics》2004,36(9):921-924
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain. 相似文献
10.
A polymorphic microsatellite that mediates induction of PIG3 by p53 总被引:16,自引:0,他引:16