The knockout mouse project |
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| Authors: | Austin Christopher P Battey James F Bradley Allan Bucan Maja Capecchi Mario Collins Francis S Dove William F Duyk Geoffrey Dymecki Susan Eppig Janan T Grieder Franziska B Heintz Nathaniel Hicks Geoff Insel Thomas R Joyner Alexandra Koller Beverly H Lloyd K C Kent Magnuson Terry Moore Mark W Nagy Andras Pollock Jonathan D Roses Allen D Sands Arthur T Seed Brian Skarnes William C Snoddy Jay Soriano Philippe Stewart David J Stewart Francis Stillman Bruce Varmus Harold Varticovski Lyuba Verma Inder M Vogt Thomas F von Melchner Harald Witkowski Jan Woychik Richard P Wurst Wolfgang |
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| Institution: | National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA. austinc@mail.nih.gov |
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| Abstract: | Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain. |
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