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A professor of biophysics and medical physics at the University of California, Berkeley, comments on advances in developing frost-resistant crop plants, and on the objections that have halted or delayed field tests of these plants. Jukes describes a proposed field trial by a biotechnology company, Advanced Genetic Sciences (AGS), of strawberry plants treated with the strains of common bacteria (Pseudomonas syringae and Pseudomonas fluorescens) from which the gene for the ice nucleation protein has been removed. Closing with an account of his confrontation with demonstrators protesting the AGS experiment, he concludes that the latter are not basing their objections on scientific fact and are failing to weigh the benefits of greater food production against the small risks from genetically altered bacteria. 相似文献
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Evolutionary nucleotide replacements in DNA. 总被引:18,自引:0,他引:18
With the increasing availability of analytical information on mRNA molecules, it is now possible to compare homologous nucleotide sequences from different organisms and to draw conclusions about their evolution. Such comparisons have shown that silent changes in codons occur more frequently than nucleotide replacements that produce changes in amino acid sequences (code-altering changes). Furthermore, there is an important difference between amino acid sequence comparisons and nucleotide sequence comparisons. The former show only differences in amino acid residues, but the latter show several types of differences when corresponding codons are compared. Single-base replacements may be degenerate (silent) or expressed as amino acid replacements. Two-base codon changes may be degenerate, single-base changes, or be visible as such. Three-base codon changes may be degenerate (involving serine), simulate either single-base or two-base changes or be visible as such. All nine types of change are found in comparisons of genes from the viruses phi X174 and G4. The relative numbers of these nine types as based on all possible interchanges between all 61 amino acid codons were listed by Holmquist et al. and are shown in Table 1. We discuss these results in the light of the significance of nucleotide changes in molecular evolution. 相似文献
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Genetic code 1990. Outlook 总被引:2,自引:0,他引:2
T H Jukes 《Experientia》1990,46(11-12):1149-1157
The genetic code is evolving as shown by 9 departures from the universal code: 6 of them are in mitochondria and 3 are in nuclear codes. We propose that these changes are preceded by disappearance of a codon from coding sequences in mRNA of an organism or organelle. The function of the codon that disappears is taken by other, synonymous codons, so that there is no change in amino acid sequences of proteins. The deleted codon then reappears with a new function. Wobble pairing between anticodons and codons has evolved, starting with a single UNN anticodon pairing with 4 codons. Directional mutation pressure affects codon usage and may produce codon reassignments, especially of stop codons. Selenocysteine is coded by UGA, which is also a stop codon, and this anomaly is discussed. The outlook for discovery of more changes in the code is favorable, and open reading frames should be compared with actual sequential analyses of protein molecules in this search. 相似文献
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T. H. Jukes 《Cellular and molecular life sciences : CMLS》1990,46(11-12):1149-1157
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