排序方式: 共有28条查询结果,搜索用时 33 毫秒
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Increased fertility in males with the sickle cell trait? 总被引:1,自引:0,他引:1
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在总结流域问题现状及流域管理决策需求的基础上,基于仿生学原理,类比人的思维特征和决策过程,提出了包括流域信息获取、输入-输出因果关联模拟以及优化决策等步骤在内的智能流域管理模式,并对比分析了智能流域管理和传统流域管理的差异性。提出了智能流域管理的4个关键问题:管理目标的确定、基于智能因子关联与流动的模型开发与信息获取、... 相似文献
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研究超声波经过两个烧结样品的行为.两个烧结样品为有序的面心立方结构,它们的结构几乎相同.研究表明:在两个有序的准均匀的介质中分别有一个禁带区域.就禁带区域而言,在两个样品中产生禁带的区域非常接近.同时在禁带出现的区域群速度为负值.我们的结果表明群速度的负值的确存在于有序介质中的禁带区域内. 相似文献
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Crystals of haemoglobin with the T quaternary structure bind oxygen noncooperatively with no Bohr effect 总被引:5,自引:0,他引:5
The relationship between the structure and function of haemoglobin has mainly been studied by comparing its X-ray crystal structures with its function in solutions. To make a direct comparison we have studied the functional properties of haemoglobin in single crystals, an approach that has been an important part of the investigation of several enzyme mechanisms. Here we report on the oxygen binding by single crystals of human haemoglobin grown in solutions of polyethylene glycol. Unlike haemoglobin crystals formed in concentrated salt solution, which crack and become disordered on oxygenation, crystals grown in polyethylene glycol remain intact. X-ray studies have shown that the T (deoxy) quaternary structure of haemoglobin in this crystal at pH 7.0 is maintained at atmospheric oxygen pressure, and that the salt-bridges are not broken. We find striking differences between oxygen binding by haemoglobin in this crystal and by haemoglobin in solution. Not only is oxygenation of the crystal noncooperative, but the oxygen affinity is independent of pH in the range 6.0-8.5, and is much lower than that of the T state in solution. The lack of cooperativity without a change in quaternary structure is predicted by the two-state allosteric model of Monod, Wyman and Changeux. The absence of a Bohr effect without breakage of salt-bridges is predicted by Perutz's stereochemical mechanism. In contrast to the X-ray result that oxygen binds only to the alpha haems, our measurements show that the alpha haems have only a slightly higher affinity than the beta haems. 相似文献
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Arginine-specific reagents remove sodium channel inactivation 总被引:3,自引:0,他引:3
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Red cell ATP and malaria infection 总被引:2,自引:0,他引:2
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Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells 总被引:17,自引:0,他引:17
R Derynck J A Jarrett E Y Chen D H Eaton J R Bell R K Assoian A B Roberts M B Sporn D V Goeddel 《Nature》1985,316(6030):701-705
The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells. 相似文献
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