排序方式: 共有4条查询结果,搜索用时 7 毫秒
1
1.
Onouchi Y Gunji T Burns JC Shimizu C Newburger JW Yashiro M Nakamura Y Yanagawa H Wakui K Fukushima Y Kishi F Hamamoto K Terai M Sato Y Ouchi K Saji T Nariai A Kaburagi Y Yoshikawa T Suzuki K Tanaka T Nagai T Cho H Fujino A Sekine A Nakamichi R Tsunoda T Kawasaki T Nakamura Y Hata A 《Nature genetics》2008,40(1):35-42
Kawasaki disease is a pediatric systemic vasculitis of unknown etiology for which a genetic influence is suspected. We identified a functional SNP (itpkc_3) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene on chromosome 19q13.2 that is significantly associated with Kawasaki disease susceptibility and also with an increased risk of coronary artery lesions in both Japanese and US children. Transfection experiments showed that the C allele of itpkc_3 reduces splicing efficiency of the ITPKC mRNA. ITPKC acts as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway, and the C allele may contribute to immune hyper-reactivity in Kawasaki disease. This finding provides new insights into the mechanisms of immune activation in Kawasaki disease and emphasizes the importance of activated T cells in the pathogenesis of this vasculitis. 相似文献
2.
M. N. Gillespie L. Diamond J. Newburger H. B. Kostenbauder 《Cellular and molecular life sciences : CMLS》1977,33(7):936-938
Summary The quaternary ammonium compound, methantheline, was found to antagonize acetylcholine induced contractions in isolated guinea pig ileum by a mechanism which did not conform to the criteria for either competitive or non-competitive inhibition. Enhancement of the lipid solubility of methantheline by formation of an ion pair with trichloracetate failed to influence its cholinergic inhibitory activity. The results suggest that in the guinea pig ileum a) an intracellular site of action does not exist for methantheline and b) the membrane receptors for methantheline most likely are located in an aqueous environment. 相似文献
3.
The quaternary ammonium compound, methantheline, was found to antagonize acetylcholine induced contractions in isolated guinea pig ileum by a mechanism which did not conform to the criteria for either competitive or non-competitive inhibition. Enhancement of the lipid solubility of methantheline by formation of an ion pair with trichloracetate failed to influence its cholinergic inhibitory activity. The results suggest that in the guinea pig ileum a) an intracellular site of action does not exist for methantheline and b) the membrane receptors for methantheline most likely are located in an aqueous environment. 相似文献
4.
1