Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

Using variants from the 1000 Genomes Project pilot European CEU dataset and data from additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously associated with immune-mediated diseases in 12,041 individuals with celiac disease (cases) and 12,228 controls. We identified 13 new celiac disease risk loci reaching genome-wide significance, bringing the number of known loci (including the HLA locus) to 40. We found multiple independent association signals at over one-third of these loci, a finding that is attributable to a combination of common, low-frequency and rare genetic variants. Compared to previously available data such as those from HapMap3, our dense genotyping in a large sample collection provided a higher resolution of the pattern of linkage disequilibrium and suggested localization of many signals to finer scale regions. In particular, 29 of the 54 fine-mapped signals seemed to be localized to single genes and, in some instances, to gene regulatory elements. Altogether, we define the complex genetic architecture of the risk regions of and refine the risk signals for celiac disease, providing the next step toward uncovering the causal mechanisms of the disease.     

生物科学专业实验教学创新教育模式的构建

分析高等院校现行的实验教学教育模式，发现存在有无法实现创新教育宗旨的弊端，通过加强创新教育理念的树立，明确专业创新能力培养的内涵，进行适应培养创新人才需要的课程体系改革，调整教学内容，改革教学的方法，建立能力水平考核方式等教学实施。构建生物科学专业实验教学新模式，从而充分发挥高等院校的优势，全面提高大学生的创新素质。