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The insulin gene VNTR, type 2 diabetes and birth weight 总被引：12，自引：0，他引：12
Ong KK Phillips DI Fall C Poulton J Bennett ST Golding J Todd JA Dunger DB 《Nature genetics》1999,21(3):262-263
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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region 总被引：1，自引：0，他引：1
Smyth DJ Cooper JD Bailey R Field S Burren O Smink LJ Guja C Ionescu-Tirgoviste C Widmer B Dunger DB Savage DA Walker NM Clayton DG Todd JA 《Nature genetics》2006,38(6):617-619
In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) on chromosome 2q24.3. We found the association in an interim analysis of a genome-wide nonsynonymous SNP (nsSNP) scan, and we validated it in a case-control collection and replicated it in an independent family collection. In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A --> G (A946T) was 0.86 (95% confidence interval = 0.82-0.90) at P = 1.42 x 10(-10). 相似文献
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