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Hadoke PW Macdonald L Logie JJ Small GR Dover AR Walker BR 《Cellular and molecular life sciences : CMLS》2006,63(5):565-578
The ability of glucocorticoids to directly alter arterial function, structure and the inflammatory response to vascular injury
may contribute to their well-established link with the development of cardiovascular disease. Recent studies have emphasised
the importance of tissue-specific regulation of glucocorticoid availability by the 11 β-hydroxysteroid dehydrogenase (11HSD)
isozymes, which inter-convert active glucocorticoids and their inactive metabolites. The expression of both type 1 and type
2 11HSDs in the arterial wall suggests that prereceptor metabolism of glucocorticoids may have a direct impact on vascular
physiology. Indeed there is evidence that 11HSDs influence glucocorticoid-mediated changes in vascular contractility, vascular
structure, the inflammatory response to injury and the growth of new blood vessels. Hence, inhibition of 11HSD isozymes may
provide a novel therapeutic target in vascular disease.
Received 19 September 2005; received after revision 1 November 2005; accepted 25 November 2005 相似文献
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