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Investigations into mechanisms that restrict the recovery of functions after an injury to the brain or the spinal cord have
led to the discovery of specific neurite growth inhibitory factors in the adult central nervous system (CNS) of mammals. Blocking
their growth-suppressive function resulted in disinhibition of axonal growth, i.e. growth of cultured neurons on inhibitory
CNS tissue in vitro and regeneration of injured axons in vivo. The enhanced regenerative and compensatory fibre growth was often accompanied by a substantial improvement in the functional
recovery after CNS injury. The first clinical studies to assess the therapeutic potential of compounds that neutralize growth
inhibitors or interfere with their downstream signalling are currently in progress. This review discusses recent advances
in the understanding of how the ‘founder molecule’ Nogo-A and other glialderived growth inhibitors restrict the regeneration
and repair of disrupted neuronal circuits, thus limiting the functional recovery after CNS injuries.
Received 5 April 2007; received after revision 28 September 2007; accepted 1 October 2007 相似文献
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