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González-Maeso J Ang RL Yuen T Chan P Weisstaub NV López-Giménez JF Zhou M Okawa Y Callado LF Milligan G Gingrich JA Filizola M Meana JJ Sealfon SC 《Nature》2008,452(7183):93-97
The psychosis associated with schizophrenia is characterized by alterations in sensory processing and perception. Some antipsychotic drugs were identified by their high affinity for serotonin 5-HT2A receptors (2AR). Drugs that interact with metabotropic glutamate receptors (mGluR) also have potential for the treatment of schizophrenia. The effects of hallucinogenic drugs, such as psilocybin and lysergic acid diethylamide, require the 2AR and resemble some of the core symptoms of schizophrenia. Here we show that the mGluR2 interacts through specific transmembrane helix domains with the 2AR, a member of an unrelated G-protein-coupled receptor family, to form functional complexes in brain cortex. The 2AR-mGluR2 complex triggers unique cellular responses when targeted by hallucinogenic drugs, and activation of mGluR2 abolishes hallucinogen-specific signalling and behavioural responses. In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis. These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis. 相似文献
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José L. Moreno Stuart C. Sealfon Javier González-Maeso 《Cellular and molecular life sciences : CMLS》2009,66(23):3777-3785
Schizophrenia is one of the most common mental illnesses, with hereditary and environmental factors important for its etiology.
All antipsychotics have in common a high affinity for monoaminergic receptors. Whereas hallucinations and delusions usually
respond to typical (haloperidol-like) and atypical (clozapine-like) monoaminergic antipsychotics, their efficacy in improving
negative symptoms and cognitive deficits remains inadequate. In addition, devastating side effects are a common characteristic
of monoaminergic antipsychotics. Recent biochemical, preclinical and clinical findings support group II metabotropic glutamate
receptors (mGluR2 and mGluR3) as a new approach to treat schizophrenia. This paper reviews the status of general knowledge
of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia 相似文献
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Nègre N Brown CD Ma L Bristow CA Miller SW Wagner U Kheradpour P Eaton ML Loriaux P Sealfon R Li Z Ishii H Spokony RF Chen J Hwang L Cheng C Auburn RP Davis MB Domanus M Shah PK Morrison CA Zieba J Suchy S Senderowicz L Victorsen A Bild NA Grundstad AJ Hanley D MacAlpine DM Mannervik M Venken K Bellen H White R Gerstein M Russell S Grossman RL Ren B Posakony JW Kellis M White KP 《Nature》2011,471(7339):527-531
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王月姣 《中南民族大学学报(自然科学版)》2003,22(4):56-57
讨论了Microsoft C语言中调用MASM 5.0汇编语言程序的方法,并针对一些易出现的问题,如程序接口部分的要求,C语言与汇编程序间参数的传递,寄存器的使用等,提出了解决办法. 相似文献
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