Natural history and evolutionary principles of gene duplication in fungi

Gene duplication and loss is a powerful source of functional innovation. However, the general principles that govern this process are still largely unknown. With the growing number of sequenced genomes, it is now possible to examine these events in a comprehensive and unbiased manner. Here, we develop a procedure that resolves the evolutionary history of all genes in a large group of species. We apply our procedure to seventeen fungal genomes to create a genome-wide catalogue of gene trees that determine precise orthology and paralogy relations across these species. We show that gene duplication and loss is highly constrained by the functional properties and interacting partners of genes. In particular, stress-related genes exhibit many duplications and losses, whereas growth-related genes show selection against such changes. Whole-genome duplication circumvents this constraint and relaxes the dichotomy, resulting in an expanded functional scope of gene duplication. By characterizing the functional fate of duplicate genes we show that duplicated genes rarely diverge with respect to biochemical function, but typically diverge with respect to regulatory control. Surprisingly, paralogous modules of genes rarely arise, even after whole-genome duplication. Rather, gene duplication may drive the modularization of functional networks through specialization, thereby disentangling cellular systems.     

太极拳干预社区中老年人亚健康状态的临床随机对照试验

目的:评价太极拳干预中老年亚健康的疗效。方法:采用随机单盲方法,将符合亚健康诊断标准的受试者100例,随机分为太极拳干预组和一般运动干预组。两组受试者分别进行每周三次,每次30min的太极拳锻炼和一般体育运动锻炼,疗程均为16周。临床疗效观察采用SF-36生命质量评分。结果:太极拳干预组生命质量干预前后评分差值与一般体育运动组比较显示:在总体健康和生命活力两个维度的差异有统计学意义。结论:太极拳较一般运动能更好地改善中老年亚健康人群生命质量。     

福建省青少年游泳运动员比赛表现的影响因素探析

采用文献资料法、问卷调查法、数理统计法,对影响福建省青少年游泳运动员比赛表现的影响因素进行研究。经过对34个因素进行因子分析,得出影响运动员比赛表现的影响因素的9个主因子。对9大因子进行分析得知,运动员比赛表现是个人技战术水平、心理能力、客观环境、人为因素、赛前准备、教练信任、对手作用、最佳体验与自我评价等多方面因素影响的结果,为我国游泳运动员训练和赛前控制比赛状态提供理论参考。     

基于人力资本视角下上海市高校体育教师培训体系的研究

运用人力资本理论,从改善上海市高校体育教师培训质量,优化体育教师人力资本等角度探讨了构建上海市高校体育教师培训体系的必要性,并设计出由培训需求评价、培训计划制定、培训过程实施与控制以及培训效果评估等各环节共同组成的科学培训体系。     

Nitrogen transfer in the arbuscular mycorrhizal symbiosis

Most land plants are symbiotic with arbuscular mycorrhizal fungi (AMF), which take up mineral nutrients from the soil and exchange them with plants for photosynthetically fixed carbon. This exchange is a significant factor in global nutrient cycles as well as in the ecology, evolution and physiology of plants. Despite its importance as a nutrient, very little is known about how AMF take up nitrogen and transfer it to their host plants. Here we report the results of stable isotope labelling experiments showing that inorganic nitrogen taken up by the fungus outside the roots is incorporated into amino acids, translocated from the extraradical to the intraradical mycelium as arginine, but transferred to the plant without carbon. Consistent with this mechanism, the genes of primary nitrogen assimilation are preferentially expressed in the extraradical tissues, whereas genes associated with arginine breakdown are more highly expressed in the intraradical mycelium. Strong changes in the expression of these genes in response to nitrogen availability and form also support the operation of this novel metabolic pathway in the arbuscular mycorrhizal symbiosis.     

拓展训练在大学生情商教育中的价值探析

情商教育是高校教育中十分重要的环节,对大学生综合素质的培养有着重要意义。目前很多大学生情商较低,拓展训练作为高校情商教育的载体,能够提高大学生自信心、毅力、合作能力、人际交往能力和认知情绪能力。     

Genome-wide, large-scale production of mutant mice by ENU mutagenesis

In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large number of mutants similar to the collections available from other model organisms such as Drosophila melanogaster and Caenorhabditis elegans. Here we report on a systematic, genome-wide, mutagenesis screen in mice. As part of the German Human Genome Project, we have undertaken a large-scale ENU-mutagenesis screen for dominant mutations and a limited screen for recessive mutations. In screening over 14,000 mice for a large number of clinically relevant parameters, we recovered 182 mouse mutants for a variety of phenotypes. In addition, 247 variant mouse mutants are currently in genetic confirmation testing and will result in additional new mutant lines. This mutagenesis screen, along with the screen described in the accompanying paper, leads to a significant increase in the number of mouse models available to the scientific community. Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html).     

当代大学生体育消费特点及倾向性之研究

我国大学生体育消费特点呈现多样化的特点:1)体育消费动机多样化;2)实物型体育消费为主、参与型、观赏型体育消费为辅;3)体育消费能力存在较大的差异性。大学生未来的体育消费倾向呈现两大特点:1)体育消费意愿呈现增长态势;2)体育消费投入出现两极分化局面。根据我国大学生体育消费特点提出以下建议:1)加大终身体育教育理念的宣传;2)加大体育消费指导;3)加快学校体育社团建设。