Rapid switching to multiple antigenic and adhesive phenotypes in malaria.

Adhesion of parasitized erythrocytes to post-capillary venular endothelium or uninfected red cells is strongly implicated in the pathogenesis of severe Plasmodium falciparum malaria. Neoantigens at the infected red-cell surface adhere to a variety of host receptors, demonstrate serological diversity in field isolates and may also be a target of the host-protective immune response. Here we use sequential cloning of P. falciparum by micromanipulation to investigate the ability of a parasite to switch antigenic and cytoadherence phenotypes. Our data show that antigens at the parasitized cell surface undergo clonal variation in vitro in the absence of immune pressure at the rate of 2% per generation with concomitant modulations of the adhesive phenotype. A clone has the potential to switch at high frequency to a variety of antigenic and adhesive phenotypes, including a new type of cytoadherence behaviour, 'auto-agglutination' of infected erythrocytes. This rapid appearance of antigenic and functional heterogeneity has important implications for pathogenesis and acquired immunity.     

百麦外用中药制剂对小鼠乳腺增生的实验研究

目的:观察外用中药制剂对小鼠乳腺增生的预防作用并探讨其机理。方法:采用苯甲酸雌二醇腹腔注射造模,分对照组、模型组与预防组。模型组与预防组腹腔注射苯甲酸雌二醇,隔天1次,并且预防组小鼠乳房涂抹百麦外用中药制剂,每天1次,共30天;对照组小鼠腹腔注射生理盐水,隔天1次,共30 d。测定各组小鼠体重变化,乳晕及乳头直径变化,血清雌激素(E2)、孕激素(P)指标,并取小鼠第二对乳房组织病理切片检查。结果:预防组与模型组小鼠体重、乳晕及乳头直径比较均有显著性差异(P0.05);预防组与模型组比较,E2水平明显降低(P0.05),P水平明显升高(P0.05);预防组小鼠增生的乳腺小叶、腺泡数、腺泡腔直径、导管直径以及胞浆面积较模型组降低。结论:百麦外用中药制剂具有预防乳腺增生的作用,其机理可能是通过抑制血清雌二醇水平而实现。     

A molecular solution to the riddle of the giant panda's phylogeny

Although it is generally agreed that the giant panda (Ailuropoda melanoleuca) is a member of the order Carnivora, there has long been disagreement over whether it should be classified with bears, raccoons or as a single member of its own family. Four independent molecular and genetic measures lead to a consensus phylogeny for the giant and lesser pandas. The lesser panda diverged from New World procyonids at approximately the same time as their departure from ursids, while ancestors of the giant panda split from the ursid lineage much later, just before the radiation which led to modern bears. The giant panda's divergence was accompanied by a chromosomal reorganization which can be partially reconstructed from the ursid karyotype, but not from that of procyonids or the lesser panda. The apparently dramatic, but actually limited, distinctions between the giant panda and the bears in chromosomal and anatomical morphology provide a graphic mammalian example of the discordance of molecular and morphological (and chromosomal) evolutionary change.     

摩擦非线性环节的特性、建模与控制补偿综述

首先介绍了机械伺服系统中摩擦非线性环节的动态、静态特性的研究成果和目前常用的几种摩擦模型 ,讨论了摩擦非线性环节对伺服系统的动态性能和静态性能的影响 ,以及摩擦非线性环节导致的极限环振荡、低速爬行等现象。然后对有关摩擦补偿方法方面的研究成果进行了总结 ,介绍了传统的摩擦补偿方法和基于智能控制理论的摩擦补偿方法方面的研究成果。最后 ,展望了该领域今后的发展方向。     

Mapping of an endogenous retroviral sequence to human chromosome 18

The application of recombinant DNA technologies has allowed the detection of at least three families of moderately repetitive DNA segments in the human genome that are homologous to retroviruses previously isolated from mice and primates. One of these DNA segments has been shown by nucleotide sequence comparisons to be distantly related to both Moloney murine leukaemia virus (MoMuLV) and the endogenous baboon retrovirus and to have the sequence organization characteristic of an integrated retrovirus. Isolation of the homologous locus from chimpanzee DNA indicated that the integration event preceded the evolutionary divergence of chimpanzees and man. Here we have used a panel of rodent x human somatic cell hybrids to assign the chromosomal localization of this segment, called ERV1 (endogenous retrovirus-1), to human chromosome 18 (HSA 18).     

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Human chromosome 2 is unique to the human lineage in being the product of a head-to-head fusion of two intermediate-sized ancestral chromosomes. Chromosome 4 has received attention primarily related to the search for the Huntington's disease gene, but also for genes associated with Wolf-Hirschhorn syndrome, polycystic kidney disease and a form of muscular dystrophy. Here we present approximately 237 million base pairs of sequence for chromosome 2, and 186 million base pairs for chromosome 4, representing more than 99.6% of their euchromatic sequences. Our initial analyses have identified 1,346 protein-coding genes and 1,239 pseudogenes on chromosome 2, and 796 protein-coding genes and 778 pseudogenes on chromosome 4. Extensive analyses confirm the underlying construction of the sequence, and expand our understanding of the structure and evolution of mammalian chromosomes, including gene deserts, segmental duplications and highly variant regions.     

Pyrogallol and vasopressin tachyphylaxis

Résumé Le pyrogallol empêche le développement d'une tachyphylaxie à la vasopressine. Il restitue la réaction pressorique après l'apparition d'une tachyphylaxie. Cet effet ne semble pas être lié à l'action inhibitrice de cette substance sur l'enzyme transférase o-méthyl.     

多参考预测链的时域可扩展性和抗错性

网络的带宽抖动和数据传输错误是影响视频传输的重要原因。该文提出了一种新的多参考帧图像预测的视频编码算法,即多参考预测链,使视频具有时域可扩展性和抗错性解决网络的这两个潜在问题。该算法中P帧之间的参考预测关系构成多条链状结构,使视频具有时域可扩展性。链间的不相关性使每个链可独立解码,从而增强了码流抗错性。该算法采用R-D框架动态的管理预测关系链,从而适合网络带宽的变化而获得最佳的终端视觉效果。仿真实验表明,采用多参考预测链编码的码流时域可扩展性的应用非常可行,且表现出较高的抗错性。