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Summary Female choice mating experiments showed virgin femaleD. melanogaster of the 3Adh genotypes chose heterozygous (Adh
F
/Adh
S
) males most commonly. Inseminated females chose mates randomly, but the likelihood of a female remating was genotypically dependent.Acknowledgment. Financial support was provided by the Australian Research Grants Commitee. 相似文献
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Zone electrophoresis of beta-lactoglobulins 总被引:1,自引:0,他引:1
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Separation of suppressor and killer T cells by surgace phenotype. 总被引:18,自引:0,他引:18
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Kopp JB Smith MW Nelson GW Johnson RC Freedman BI Bowden DW Oleksyk T McKenzie LM Kajiyama H Ahuja TS Berns JS Briggs W Cho ME Dart RA Kimmel PL Korbet SM Michel DM Mokrzycki MH Schelling JR Simon E Trachtman H Vlahov D Winkler CA 《Nature genetics》2008,40(10):1175-1184
The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in populations of African ancestry has been largely unexplained. To identify genetic variants predisposing to idiopathic and HIV-1-associated focal segmental glomerulosclerosis (FSGS), we carried out an admixture-mapping linkage-disequilibrium genome scan on 190 African American individuals with FSGS and 222 controls. We identified a chromosome 22 region with a genome-wide logarithm of the odds (lod) score of 9.2 and a peak lod of 12.4 centered on MYH9, a functional candidate gene expressed in kidney podocytes. Multiple MYH9 SNPs and haplotypes were recessively associated with FSGS, most strongly a haplotype spanning exons 14 through 23 (OR = 5.0, 95% CI = 3.5-7.1; P = 4 x 10(-23), n = 852). This association extended to hypertensive ESKD (OR = 2.2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans. 相似文献
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Zusammenfassung Die kontraktile Reaktion des isolierten Meerschweinchen-Ileums auf Angiotensin II variierte direkt mit der Natriumkonzentration der Nährflüssigkeit, nicht aber bei ACh; Atropin (10–6 g/ml) reduzierte die Wirkung auf Angiotensin um 60–70% und hob die Wirkung auf äquivalente Mengen von ACh auf. In atropinhaltiger Ringerlösung potenzierte ein hoher Natriumgehalt (+ 30 meq./l) die Reaktion auf Angiotensin zehnfach. 相似文献
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The relative motion between the plates on each side of the East African Rift Valley can be obtained from the opening of the Red Sea and the Gulf of Aden. The calculated direction of relative motion agrees well with fault plane solutions for earthquakes north of the equator. 相似文献
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Ed. McKenzie 《Journal of forecasting》1984,3(3):333-344
Although the basic principles of exponential smoothing and discounted least squares are easily understood, the full power of the technique is only rarely exploited. The reason for this failure lies in the complexity of the standard procedures. Often they require fairly complex mathematical models and use a variety of cumbersome algebraic manipulations. An alternative formulation for exponential smoothing is presented. It simplifies these procedures and allows an easier use of the full range of models. This new formulation is obtained by considering the relationship between general exponential smoothing (GES) and the well-known ARMA process of Box and Jenkins. The three commonest seasonal models have only recently been considered for GES systems. They are discussed in some detail here. The computational requirements of the GES and equivalent ARMA procedures are reviewed and some recommendations for their application are made. The initialization of GES forecasting systems and the important problem of model selection is also discussed. A brief illustrative example is given. 相似文献