基于Wiener滤波器的波形比较方法及其在最坏情况分析中的应用

提出一种基于Wiener滤波器的波形比较方法,应用于数模混合电路的最坏情况分析.该方法能考虑一定的时间容限和信号容限,自动比较电路在不同的工艺参数、电压和温度(PVT)组合下的仿真波形,通过波形形状的比较来实现电路性能验证,有效地提高了电路验证效率.此方法成功地运用到波形比较软件系统中,并已在Intel技术开发(上海)公司内部推广使用.     

Diffusion of d-glucose measured in the cytosol of a single astrocyte

Astrocytes interact with neurons and endothelial cells and may mediate exchange of metabolites between capillaries and nerve terminals. In the present study, we investigated intracellular glucose diffusion in purified astrocytes after local glucose uptake. We used a fluorescence resonance energy transfer (FRET)-based nano sensor to monitor the time dependence of the intracellular glucose concentration at specific positions within the cell. We observed a delay in onset and kinetics in regions away from the glucose uptake compared with the region where we locally super-fused astrocytes with the d-glucose-rich solution. We propose a mathematical model of glucose diffusion in astrocytes. The analysis showed that after gradual uptake of glucose, the locally increased intracellular glucose concentration is rapidly spread throughout the cytosol with an apparent diffusion coefficient (D _app) of (2.38 ± 0.41) × 10^?10 m² s^?1 (at 22–24 °C). Considering that the diffusion coefficient of d-glucose in water is D = 6.7 × 10^?10 m² s^?1 (at 24 °C), D _app determined in astrocytes indicates that the cytosolic tortuosity, which hinders glucose molecules, is approximately three times higher than in aqueous solution. We conclude that the value of D _app for glucose measured in purified rat astrocytes is consistent with the view that cytosolic diffusion may allow glucose and glucose metabolites to traverse from the endothelial cells at the blood–brain barrier to neurons and neighboring astrocytes.     

Understanding Scientific Study via Process Modeling

This paper argues that scientific studies distinguish themselves from other studies by a combination of their processes, their (knowledge) elements and the roles of these elements. This is supported by constructing a process model. An illustrative example based on Newtonian mechanics shows how scientific knowledge is structured according to the process model. To distinguish scientific studies from research and scientific research, two additional process models are built for such processes. We apply these process models: (1) to argue that scientific progress should emphasize both the process of change and the content of change; (2) to chart the major stages of scientific study development; and (3) to define “science”.     

全球电视需求攀升 带动中国电视产业

<正>以目前的态势看,虽然现在中国企业在劳工方面的问题会对中国制造的低成本优势形成挑战,但是来自中国的电视生产企业将可能会占据新型超大屏幕超薄电视市场的最大份额。就在平板液晶电视的全球需求飙升之际,索尼公司     

数字信号处理（DSP）算法的合成和优化

本书详细介绍了数字信号处理器的硬件合成和硬件定制实现的优化方法领域的研究动态，高层次的讨论了在满足用户给定的限制条件下，如何自动化进行高性能一面积比（area—efficient）设计的技术，指出了这类技术可以用于线性系统和非线性系统：包括有限长脉冲（FIR）和无限长脉冲（IIR）滤波器、离散余弦变换（DCT）、多相滤波器组和自适应最小均方（LMS）滤波器。     

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV breakpoints within the HBV genome were located within a 1,800-bp region where the viral enhancer, X gene and core gene are located. We also identified recurrent HBV integration events (in ≥ 4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue. We also report evidence that suggests that the number of HBV integrations is associated with patient survival.     

Experimental investigation of geologically produced antineutrinos with KamLAND

The detection of electron antineutrinos produced by natural radioactivity in the Earth could yield important geophysical information. The Kamioka liquid scintillator antineutrino detector (KamLAND) has the sensitivity to detect electron antineutrinos produced by the decay of 238U and 232Th within the Earth. Earth composition models suggest that the radiogenic power from these isotope decays is 16 TW, approximately half of the total measured heat dissipation rate from the Earth. Here we present results from a search for geoneutrinos with KamLAND. Assuming a Th/U mass concentration ratio of 3.9, the 90 per cent confidence interval for the total number of geoneutrinos detected is 4.5 to 54.2. This result is consistent with the central value of 19 predicted by geophysical models. Although our present data have limited statistical power, they nevertheless provide by direct means an upper limit (60 TW) for the radiogenic power of U and Th in the Earth, a quantity that is currently poorly constrained.     

基于DSP实现的通用双随机PWM方案

提供了一种新的双随机脉冲调制技术，它能够很好地减小电力电子系统中存在的传导电磁干扰，这个调制技术是通过同时改变开关频率和脉冲的上升沿位置来实现的。与已经存在的任何一种单随机方案相比，双随机调制技术驱散谐波能量而使之具有更宽的带宽，能更加有效地减少功率变换器系统的离散谱峰值。给出了基于三菱数字信号处理器实现双随机PWM调制信号的技术及其实验结果。