西文期刊回溯建库中几个重要项目的著录

在实践的基础上，从期刊的出版日期、出版周期、卷、期、年、月及其他标识、ISSN、增刊、出版者以及期刊的历史发展等方面对西文期刊机读目录的标准化著录问题进行了探讨。     

关于21世纪图书馆员继续教育问题的思考

论述了21世纪对图书馆员进行继续教育的必要性，介绍了图书馆员继续教育的内容，针对我国图书馆员继续教育的状况，提出了应采取加大投入、进行针对性培训、运用激励机制等措施来加强对图书馆员的继续教育。     

合成烯丙基砜的新方法

报道一种简单、便利的一步合成烯丙基砜的新方法。     

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism

The metabolism of all-trans- and 9-cis-retinol/ retinaldehyde has been investigated with focus on the activities of human, mouse and rat alcohol dehydrogenase 2 (ADH2), an intriguing enzyme with apparently different functions in human and rodents. Kinetic constants were determined with an HPLC method and a structural approach was implemented by in silico substrate dockings. For human ADH2, the determined K_m values ranged from 0.05 to 0.3 μM and k_cat values from 2.3 to 17.6 min⁻¹, while the catalytic efficiency for 9-cis-retinol showed the highest value for any substrate. In contrast, poor activities were detected for the rodent enzymes. A mouse ADH2 mutant (ADH2Pro47His) was studied that resembles the human ADH2 setup. This mutation increased the retinoid activity up to 100-fold. The K_m values of human ADH2 are the lowest among all known human retinol dehydrogenases, which clearly support a role in hepatic retinol oxidation at physiological concentrations. Received 12 October 2006; received after revision 6 December 2006; accepted 8 January 2007     

关于西藏高校“计算机文化”课程教学考核改革思考

在科技迅速发展的今天,信息化管理及其人们对新信息的需求程度不断提高,计算机技术的应用日益深入到各行各列,西藏高校的"计算机文化"课程的教学方法和考核方式都迫切需要改革。文章在教学实践的基础上,对我区高校"计算机文化"课程的教学方法及考核方式改革进行了探索。     

DEDS的模拟退火仿真优化方法

本文对模拟退火优化方法进行了修改,使它能较好地适应于DEDS的仿真优化研究.文中对两种优化状态下,仿真目标值之差的估计误差性质进行了分析,并对修正后算法收敛的最优性进行了理论证明。     

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases.

Astacin, a digestive zinc-endopeptidase from the crayfish Astacus astacus L., is the prototype for the 'astacin family', which includes mammalian metallo-endopeptidases and developmentally regulated proteins of man, fruitfly, frog and sea urchin. Here we report the X-ray crystal structure of astacin, which reveals a deep active-site cleft, with the zinc at its bottom ligated by three histidines, a water molecule and a more remote tyrosine. The third histidine (His 102) forms part of a consensus sequence, shared not only by the members of the astacin family, but also by otherwise sequentially unrelated proteinases, such as vertebrate collagenases. It may therefore represent the elusive 'third' zinc ligand in these enzymes. The amino terminus of astacin is buried forming an internal salt-bridge with Glu 103, adjacent to His 102. Astacin pro-forms extended at the N terminus, as observed for some 'latent' mammalian astacin homologues, did not exhibit this 'active' conformation, indicating an activation mechanism reminiscent of trypsin-like serine proteinases.     

花岗岩磨削磨粒破碎性能研究

花岗岩是一种含硅酸量较多的酸性深层岩。目前国内的石材加工由于磨削工艺不尽合理,磨削质量不符要求,因而需依靠进口磨具。本实验通过不同磨料对不同花岗岩进行单颗粒磨削,探索其规律,为合理选择和使用磨具提供理论依据。     

混凝土未测区域质量预测方法研究

文章针对桩基超声波测试评价桩身混凝土质量，提出了回归分析、灰色理论和三次样条函数三种方法在预测未知区域的应用。尤其三次样条法有较好的应用前景，为桩基可靠度评价提供了保证。     

预测我国钢铁工业发展趋势的递归模型

本文根据我国钢铁工业生产特点,建立了60多个变量、28个方程的递归模型,描述了钢铁工业生产的结构形式,确定了主要生产环节的生产函数,给出了各种经济变量间的相互关系,预测了我国矿、铁、钢、钢材、产值等28个主要的内生变量的未来值,分析了“七五”、“八五”、“九五”三个五年计划可达指标、发展速度及保证条件。经过1984年的实际检验,证明模型的预测效果良好。