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Koenigs M  Young L  Adolphs R  Tranel D  Cushman F  Hauser M  Damasio A 《Nature》2007,446(7138):908-911
The psychological and neurobiological processes underlying moral judgement have been the focus of many recent empirical studies. Of central interest is whether emotions play a causal role in moral judgement, and, in parallel, how emotion-related areas of the brain contribute to moral judgement. Here we show that six patients with focal bilateral damage to the ventromedial prefrontal cortex (VMPC), a brain region necessary for the normal generation of emotions and, in particular, social emotions, produce an abnormally 'utilitarian' pattern of judgements on moral dilemmas that pit compelling considerations of aggregate welfare against highly emotionally aversive behaviours (for example, having to sacrifice one person's life to save a number of other lives). In contrast, the VMPC patients' judgements were normal in other classes of moral dilemmas. These findings indicate that, for a selective set of moral dilemmas, the VMPC is critical for normal judgements of right and wrong. The findings support a necessary role for emotion in the generation of those judgements.  相似文献   
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In order to become aware of inconsistencies, one must first construe of the world in a way that reflects its consistencies. This paper begins with a tentative model for how a set of discrete memories transforms into an interconnected worldview, wherein relationships between memories are forged by way of abstractions. Inconsistencies prompt the invention of new abstractions. In regions of the conceptual network where inconsistencies abound, a cognitive analog of simulated annealing is in order; there is a willingness to question previous assumptions - to ‘loosen’ conceptual relationships - so as to let new concepts percolate through the worldview and exert the needed revolutionary effect. In so doing there is a risk of assimilating dangerous concepts. Repression arrests the process by which dangerous thoughts infiltrate the conceptual network, and deception blocks thoughts that have already been assimilated. These forms of self-initiated worldview inconsistency may evoke feelings of fragmentation at the level of the individual or the society. This revised version was published online in July 2006 with corrections to the Cover Date.  相似文献   
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分析和比较MRA 和CDFI诊断颈动脉狭窄的准确性,评估MRA 作为颈动脉影象检查的诊断价值.35 例颈动脉MRA 全部在Siemens Magnetom Impact 1 .0 磁共振机器上扫描,MRA扫描序列为2 维时间飞跃技术颈动脉狭窄均经CDFI确诊CDFI用Acuson128 彩色双功能多普勒诊断仪MRA 清晰地显示正常颈动脉的颈内动脉、颈外动脉及颈动脉分叉轻度颈动脉狭窄MRA 表现为沿血管壁的信号丢失血流信号中断是颈动脉狭窄的特征,中度颈动脉狭窄伴有狭窄后扩张,重度颈动脉狭窄则狭窄后血管细窄颈动脉血流消失并无血流重现是血管闭塞特异征象MRA 分级颈动脉狭窄程度和CDFI一致性良好MRA 评价颈动脉非常有价值,是诊断颈动脉狭窄的一种有特征性的新方法  相似文献   
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