打造新时代创新策源地——以湖北科技特派员制度为例

湖北省多年来深入推行科技特派员制度,在全国科技特派员制度推行和科技服务的伟大实践中拼搏奋进,从启动科技特派员地市试点工作,到全面开展科技特派员基层创业行动,从出台深入推行科技特派员制度实施意见,到开展湖北省科技特派员"百县千镇万人"工程实施,围绕产业链布局人才链的科技生态日臻完善.科技特派员个人、团队和法人单位点面结合,工作室与工作站交相辉映,他们立足湖北服务华中片区和秦巴山区,辐射服务全国各地,湖北科技特派员的服务足迹遍布荆楚星辰大地,谱写着新时代湖北科技特派员服务体系的新篇章.     

基于知识图谱的核电设备健康管理知识建模与分析

随着信息技术发展,设备健康数据与知识图谱技术结合为设备健康发展带来新的发展机遇,知识图谱利用其多种特异性优势,使企业系统中积累的海量设备维修数据得到有效整合利用.本文提出基于知识图谱的核电设备健康管理知识建模与分析方法,并根据实体关系模型构建维修知识图谱本体框架,同时基于核电企业实际的维修工单数据,从统计分析和关联分析两方面取得良好的实践效果.研究结果表明,知识图谱能够在设备维修知识的集成上解决传统的数据孤岛问题,同时能基于故障的可视化分析为维修人员和管理人员提供决策和知识支持.     

Controllability of Quantum Systems with SU(1, 1) Dynamical Symmetry

This paper presents sufficient and necessary conditions for the propagator controllability of a class of infinite-dimensional quantum systems with SU(1, 1) dynamical symmetry through the isomorphic mapping to the non-unitary representation of SU(1, 1). The authors prove that the elliptic condition of the total Hamiltonian is both necessary and sufficient for the controllability and strong controllability. The obtained results can be also extended to control systems with SO(2, 1) dynamical symmetry.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

时标轴上二阶Dirichlet边值问题的弱解（英文）

采用变分方法和临界点理论研究一个时标轴上二阶Dirichlet边值问题弱解的存在性.     

氧化还原介体催化强化污染物厌氧降解研究进展

 由于厌氧生物处理技术具有产生剩余污泥少、可回收能源等优点而被广泛用于处理各种有机污染物，尤其在有毒、有害、难降解污染物的去除方面取得了良好的效果。然而，厌氧生物法的处理速率通常比较低，而氧化还原介体可通过自身不断的氧化和还原来传递电子，提高电子在氧化还原反应过程中的传递速率，从而促进污染物高效厌氧降解。醌类物质和腐殖酸是应用较多的氧化还原介体，在催化难降解污染物降解方面取得了一定效果。讨论了氧化还原介体的特点、作用机制，并总结了其对偶氮染料厌氧脱色、反硝化和多氯联苯厌氧降解的强化作用，提出了氧化还原介体未来的研究方向。     

关于二面体群的共轭类长素图

讨论二面体群的结构问题,利用GAP软件给出二面体群D2n的共轭类长素图,并完整给出当n以及n/2分别是奇数和偶数时的共轭类长素图情况.     

A Layer-Stripping Method for 3D Near-Surface Velocity Model Building Using Seismic First-Arrival Times

In order to improve the efficiency of 3D near-surface velocity model building, we develop a layer-stripping method using seismic first-arrival times. The velocity model within a Common Mid-Point (CMP) ...     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

An Economic Model-Based Matching Approach Between Buyers and Sellers Through a Broker in an Open E-Marketplace

A broker in an open e-marketplace enables buyers and sellers to do business with each other. Although a broker plays an important role in e-marketplaces, theory and guidelines for matching between buyers and sellers in multi-attribute exchanges are limited. Therefore, a challenge for a broker’s responsibility is how to maximize a buyer’s total satisfaction degree as its goals under the consideration of trade-off between a buyer’s buying quantity and price paid to a seller, and other attributes. To solve this challenge, this paper proposes an economic model-based matching approach between a buyer’s requirements and a seller’s offers. The major contributions of this paper are that (i) a broker can model a seller’s price policy as per a buyer’s buying quantity through communication between a broker and a seller; (ii) due to each buyer’s different quantity demand, a broker models a buyer’s satisfaction degree as per a buyer’s buying quantity based on communication between a broker and a buyer; and (iii) to carry out a broker’s matching processes, an objective function and a set of constraints are generated to help a broker to maximize a buyer’s total satisfaction degree. Experimental results demonstrate the good performance of the proposed approach.