Modeling of DSBs Generation and Repair Process under Ion Radiation

Under acute perturbations from outside, cell can trigger the self-defense mechanisms in fighting against these genome stresses. To simulate the investigation of the complicated mechanisms of cellular responding DNA damage at single cell level, a model of the double strand breaks (DSBs) generation and repair process is proposed under continuous effect of acute IR. Under different IR dose domains, this model can be used to simulate the complicated interactions among vital components within the cell, and the plausible outcomes of cellular response in fighting against DNA damage.     

DNA损伤下的P53基因调控网络建模与仿真

作为关键调控因子之一,P53在响应DNA损伤期间通过启动下游基因及其调控通路实现细胞周期捕获,促进病变细胞凋亡等系统功能。P53基因调控网络对于肿瘤形成与治疗研究都起到了积极的促进作用。旨在通过数学模型对单细胞内部响应外界干扰而产生的复杂调控机制进行研究,建立了DNA损伤下的P53基因调控网络动力学模型,利用微分方程方法分别实现了各子模块响应离子辐射的详细过程;通过Matlab7.0仿真平台实现了DNA损伤修复,ATM（ataxia telangiectasia mutated）激活以及P53-MDM2等模块间的动态调控过程;通过仿真结果简要分析了ATM激活时间阈值以及P53与MDM2（Mouse double minute two）基因响应离子辐射而产生的周期震荡等特性。