Parasite fauna of the grey mullet Mugil cephalus L. 1758, and its relationship with some ecological factors in Lower Kızılırmak Delta located by the Black Sea,Turkey

Parasites of the grey mullet Mugil cephalus collected from Lower K?z?l?rmak Delta in Turkey were investigated. Trichodina puytoraci, Trichodina lepsii, Ligophorus mediterraneus, Ligophorus cephali, Gyrodactylus sp., Microcotyle mugilis, Ascocotyle (Phagicola) longa, Haplosplanchnus pachysomus, Diplostomum spathaceum, Tylodelphys clavata, Posthodiplostomum sp., Neoechinorhyncus agilis and Ergasilus lizae were identified. Overall infection prevalence (%), mean intensity and mean abundance values were 99.61%, 458.10 ± 75.72 and 456.30 ± 75.44, respectively. Infection indices of parasite species in relation to season, lakes/lagoons and some physicochemical parameters of water such as temperature, salinity, dissolved oxygen and nitrate are determined and discussed. Posthodiplostomum sp. is a new parasite record for mugilids and Diplostomum spathaceum is the first record in M. cephalus, in the present study. Moreover, Ligophorus mediterraneus, Ligophorus cephali and Ergasilus lizae are new records for Turkish parasite fauna of fish and Mugil cephalus is a new host record for Neoechinorhyncus agilis in Turkey.     

高职院校应用法语专业复合型人才培养初探

随着市场对人才需求的多样化和人们对人才认识的深入,高职教育成为教育事业中一股新生力量,逐渐被企业重视。高职教育培养的人才多是实用型人才,能够快速进入工作岗位创造财富。所以高职教育和普通高校的教育存在一定的区别,要更加重视知识的应用性。在外语方面的教育更是如此,不仅仅要重视外语基础知识的教学,更要重视其应用教学,使其在使用中得到检验,在应用中得到锻炼。而法语作为小语种中的一个重要分支,在对外交流和公司合作方面有着重要的应用。该文通过对法语应用特点的总结,详细介绍了法语复合型人才的培养方法。     

2种山姜属植物挥发性成分的GC-MS分析

采用同时蒸馏萃取法提取桂南山姜茎叶和毛红豆蔻茎叶的挥发油,以不同的毛细管柱进行分析,找出最佳的分析条件,用归一化法测定各个成分的相对含量,并利用气相色谱-质谱联用技术(GC-MS)对其化学成分进行分析鉴定.从桂南山姜茎叶的挥发油中分离鉴定出了65个化合物,占其挥发油总成分的95.40%;从毛红豆蔻茎叶的挥发油中分别分离鉴定出了71个化合物,占其挥发油总成分的92.38%.     

民办高校中工科类实训课教学的优化

工科类实训课是我院本、专科工科学生的重要的实践教学课程。本课题主要是对我院工科类的实训课程旧的教学模式存在的问题和不足进行收集和总结,然后有针对性地从教学方法、教学手段、师资队伍、教学资源上进行一系列的优化,不但使学生通过实训课在实践动手能力上真正得到锻炼和提高,更重要的是使学生的实训课安全得到了保障。同时实现资源共享,减少民办高校的办学成本。目的在于培养出符合民办高校培养应用型人才的目标。     

基于光诱导荧光的维生素K1检测方法研究

建立一种灵敏度高、选择性好的基于紫外光诱导荧光的维生素K1(VK1)检测方法.不发荧光的VK1经紫外光(254nm,15W)照射后可转变为具有很高荧光量子产率的光化产物,检测出其特征荧光峰在465nm处;当加入咪唑并经光诱导后,光化产物荧光特性发生变化,在330nm处又出现一新的较强荧光发射峰,两峰间的stokes位移长达135nm.同时发现,随着VK1浓度的增加,465nm处的荧光峰强度增加,而330nm处的峰强度反而减小.方法的检出限为0.003#g·mL-1(S/N=3),对1.0#g·mL-1 VK1溶液进行11次平行测定,相对标准偏差(RSD)为2.4%.该法用于注射液及人血清中VK1含量测定,回收率为97%~104%,结果令人满意.     

混凝土塑性损伤模型参数的研究

基于相关的试验研究成果,提出了一种确定混凝土塑性损伤模型(KC模型)强度参数取值的方法.针对KC模型损伤参数取值依赖于单元尺寸的问题,以我国混凝土规范为基准,阐述了损伤参数值的调整方法,使得数值计算结果更加合理.利用ANSYS/LSDYNA模拟混凝土常规三轴压缩试验,KC模型分别采用本文确定和程序自动生成的强度参数值,并将计算结果与国内外试验结果比较,研究表明:采用本文提出的方法确定KC模型强度参数值比较合理.     

基于C语言的排序算法在五年制高职课堂中的应用

排序算法是C语言的重点和难点。研究排序算法中具有代表性的冒泡排序算法和选择排序算法。认真分析教学对象和教学内容的特点,细化教学过程,创新教学手段,可以减少学生对C语言学习的恐惧心理,取得较好的学习效果。     

Millennial climate changes since MIS 3 revealed by element records in deep-sea sediments from northern South China Sea

High resolution elemental MD05-2903 from the northern South records in core China Sea were obtained from XRF scanning and grain size and mineral component analyses. The K/Ti curve reveals climate changes since MIS 3 on a millennial scale, representing one of the best such records so far from deep-sea sediments of the South China Sea. When compared our K/Ti record with other climate records from high latitude ice cores and from East Asia stalagmites, variations in the K/Ti record show some typical saw-shaped features of rapid climate changes in the Northern Hemisphere. Grain size analysis reveals a close relationship between variations in K/Ti and in the fine end-member grain size. XRD analysis confirms that high K/Ti layers were dominated by K-rich weathering minerals, especially illite, while low K/Ti layers contain low illite but high abundance of Ti-rich heavy minerals. Therefore, the K/Ti record reflects changes in the input and deposition of fine weathering minerals and heavy minerals in the northern South China Sea region during stadials and interstadials. These elemental changes were largely con- trolled by variations in rainfall, erosion, and fluvial trans- portation induced by East Asia Monsoon.     

论社会主义网络文化自觉的提升途径

网络文化自觉程度的高低,不仅决定着文化品质的优劣,而且关系到国家与民族的文明进程。如何有效激发并提升社会主义网络文化自觉,已经显得异常迫切和重要。为此,需要以马克思主义网络化为指导,以道德自觉自律为基础,以文化与科技的融合为支撑,以传统文化的现代化和网络化为根本,以政府的文化自觉自省为主导,达到提升社会主义网络文化自觉的目的,并以此促进社会主义先进文化的创新力度,有效地加快社会主义文化的发展进程。     

Metformin targets liver tumor-initiating cells through the PI3K/Akt/mTOR survival pathway

Liver tumor-initiating cells （T-ICs） are thought to be inherently resistant to the cytotoxic effects of chemo- therapy, and can self-renewal and maintain tumor-initiating potential. Therefore, effective anticancer research strategies should target the unique properties of T-ICs. In this study, we found that metformin, a first-line drug of choice for the treatment of type 2 diabetes, inhibited liver T-ICs both in vivo and in vitro. Metformin inhibited the formation of hepato- spheres and epithelial-specific antigen-positive （ESA, CD133＋） cell colonies by hepatocellular carcinoma （HCC） cell lines. Metformin also downregulated the expression of several T-IC-related genes which are involved in the signal- ing pathways, governing the self-renewal, proliferation and differentiation of T-ICs. Furthermore, the targeting of liver T-ICs by metformin was PI-3-kinase-Akt-mTOR （PI3K/Akt/ mTOR）-pathway dependent. The PI3K/Akt/mTOR inhibitorLY294002 and rapamycin abolished the inhibitory effect of metformin on CD133＋ cells, and the PI3K/Akt/mTOR stimulator EGF promoted the inhibitory effect of mefformin on CD 133＋ cells. Metformin also dramatically decreased the tumor volume and number of CD133 expressing tumor cells in a xenograft mouse model. Mefformin exerted a synergistic effect with cisplatin to target both T-ICs and non-T-ICs, and resulted in the smallest tumor volume and lowest number of CD133 expressing tumor cells. This study indicates that the antidiabetic drug metformin could potentially be used in combination therapy with chemotherapeutic agents to improve the treatment of liver cancer.