Review of galactic and extragalactic searches for class I methanol masers

Class I methanol masers are important tools for investigations of star formation throughout the Universe. Recently, a series of surveys for class I methanol masers at the 95 GHz transition toward samples of young stellar objects have been undertaken. These surveys have resulted in the detection of about 200 new class I methanol masers and combined with previous increased the number of known observations they have class I methanol masers in our Galaxy to ~400. From analysis of the relationship between class I methanol maser emission and associated astrophysical objects, it has been shown that the intensity of the class I methanol maser emission is closely correlated with the properties of the 1.1 mm Bolocam Galactic Plane Survey （BGPS） dust continuum sources and outflow properties. This further supports the hypothesis that class I methanol masers are collisionally pumped and excited in shocked regions. Based on these observations, it can be inferred that the BGPS catalog is likely to provide more reliable samples for targeting further class I methanol maser searches. A new survey for class I methanol masers toward a larger size sample of BGPS sources to test this is currently underway. The prospects for detecting class I methanol megamasers in extragalactic sources is discussed, and observations constituting the first sensitive search have been proposed.     

Scalable manufacturing methodologies for improving adeno-associated virus-based pharmaprojects

Adeno-associated virus （AAV） is a promising viral vector and meets most requirements of being a safe biological agent. However, the commercialization of AAV has been hampered due to the limitation of large-scale production, and only a small number of clinical trials have been launched. In recent years, progresses in scalable manufacturing of AAV have dramatically improved AAV- based clinical researches, and have assisted the develop- ment of investigational drug products. An AAVl-based investigational product, Glybera, has been formally approved by European Commission for the treatment of lipoprotein lipase deficiency （LPLD）. Glybera was the first gene therapy product in the western world, and the pro- duction process involves a scalable baculovirus-insect cell system. However, many problems still need to be solved to improve the productivity and quality of AAV. The present review gives critical insights into current state-of-the-art scalable producing methodologies of AAV, such as bacu-lovirus-insect cell system, HSV complementation system, and Ad complementation system, along with a discussion on the problems, solutions, and developmental trends.Novel AAV-producing platforms in Saccharomyces cere- visiae and vaccinia virus complementation system will also be discussed.     

Multifractal analysis of resting state fMRI series in default mode network: age and gender effects

Age-related changes of resting state in default mode network （DMN） may provide new clues to the developing mechanism of normal brain as well as early diagnosis and therapy of some neuropsychiatric disorders. The application of multifractal theory to functional magnetic resonance imaging （fMRI） signals has recently raised increasing attention. We aim to explore the multifractal characteristics underlying the resting state functional magnetic resonance imaging （rs-fMRI） series extracted from DMN, and two issues are mainly discussed： （1） whether there exist multifractals in rs-fMRI series; （2） whether it is possible to distinguish between the different ages or genders by means of multifractal characteristics. Results demon- strated the existence of multifractals in rs-fMRI series in DMN. In addition, slight differences between young subjects and middle-aged or elderly subjects can be successfully detected by △asα, a modified measure we proposed. Furthermore, it is revealed that the rs-fMRI series from young subjects possess smaller averaged scale index and weaker long range correlation, while those from middle-aged or elderly people present increasing averaged scale index andstronger long range correlation. Whereas no significant statistical differences has been found between male and female group. Our results, therefore, highlight the potential useful- ness of multifractal analysis in fMRI series of a certain brain region, and provide important insights into healthy aging in DMN.     

投稿须知

<正>《青海师范大学学报(自然科学版)》是经国家新闻出版署批准,国内外公开发行的综合性学术刊物。主要刊登数学、物理、计算机、化学、生物、地理、体育及相关学科的学术论文。本刊对来稿有如下要求:1.投稿信箱:xuebao@qhnu.edu.cn2.来稿结构顺序:篇名、作用署名、工作单位、所在城市及邮编、摘要(200字以内)、关键词(3~8个)、中     

半群H_n的每个星理想的秩和幂等元秩

设H n是自然序集X n={1,2,3,…,n}(n≥3)上的保降序且保序有限奇异变换半群,记H(n,r)={α∈H n:|Imα|≤r}为半群H n的双边星理想.对1≤r≤n-1,刻划了H(n,r)是由秩为r的幂等元生成的且它的秩和幂等元秩都等于Cr-1n-1.进一步证明了当l=r时,r(H(n,r),H(n,l))=0且当1≤lr时,r(H(n,r),H(n,l))=Cr-1n-1.     

数字图像相关法中的优化插值滤波器

针对数字图像相关方法中的亚像素插值误差,在复频域内利用滤波器的传递函数分析了亚像素位置和图像频率对插值误差的影响,在此基础上设计了一种基于B样条插值核的优化插值滤波器。为使该滤波器能自适应于不同散斑图像,提出了一种利用图像的频谱分析获取滤波器中权值函数的方法,以B样条滤波器系数为非线性优化插值滤波器的迭代初值,解算出图像的最优滤波系数。在不考虑数字图像相关法中其他位移测量误差影响的情况下,通过平移和单向拉伸两个数值实验,证实所提滤波器可以明显减小亚像素插值误差,更好地满足了实验力学中对利用数字图像相关法进行高精度位移测量的需求。     

一个关于{1,2,…,n}排列的猜想

我们证明了孙智伟的下述猜想:对任意不等于3的正整数n,存在{1,2,dots,n}的一个全排列(a1,…,an)使得a1＝1,an =n,并且a1 +a2,a2+a3,…,an-1 +an,an +a1都与n互素.     

时域光学拓扑成像方法的模拟和实验研究

针对现有的以修正的朗伯-比尔定律(modified Lambert-Beer law,MLBL)为理论模型的光学拓扑方法存在量化度不准确的问题,提出了一种基于最小二乘拟合算法的时域光学拓扑成像方法.该方法利用时域扩散方程在半无限空间条件下的解析解和测量曲线实现最佳匹配以计算相邻的源点与探测点之间的待测组织吸收系数变化值.对该时域光学拓扑成像方法进行了一系列的模拟验证,并以基于时间相关单光子计数(time-correlated single photon counting,TCSPC)技术的多通道时间分辨测量系统为平台进行了实验验证.结果表明:所提出的最小二乘拟合算法总体上优于传统的基于经验值光程的MLBL方法.     

基于最大互邻集合的无线传感器网络单向时间同步

时间同步是无线传感器网络的一项关键技术。针对目前时间同步算法能耗较大等问题,通过单向同步技术建立全网同步数学模型,提出一种基于最大互邻集合的同步算法。在层次发现阶段生成同层节点的最大互邻集合,利用有限的消息交互分布式地保留尽量少的广播节点,并加入子节点注册、低层节点监听和时序控制等策略提高算法效率。在NS2软件平台进行了仿真,并与相关文献算法对比,结果表明所提出的算法在达到相同同步精度前提下,可显著降低同步阶段的消息开销,提高成功同步节点比例。     

用3D打印“智”造生活

<正>近日,一份名为《2013年浙江省3D打印产业发展报告》的文件在浙江省3D打印产业联盟单位内部工作人员手中传阅。2013年是浙江省3D打印产业发展的元年,省3D打印产业联盟成立,联盟成员迅速扩展。有数据表明,与3D打印相关的产业发展迅猛,其中涉及装备开发的企业有9家、材料开发企业5家、软件开发企业3家、应用服务企业28家,浙