PVP治疗骨质疏松性椎体压缩骨折术后24 h疗效分析

为了探讨影响经皮椎体成形术(percutaneous vertebroplasty, PVP)治疗骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fractures, OVCF)术后24 h手术效果的影响因素,通过回顾性分析2015年1月—2022年1月邯郸市中心医院骨五科行PVP治疗的351名OVCF患者,根据Macnab量表将术后24 h手术效果分类,将患者分为满意组(A)和不满意组(B),分析患者骨折时间、术前VAS(visual analogue scale)评分、抑郁症病史等相关因素,将有统计学意义的变量进行二元Logistic回归分析。结果表明：两组比较,患者骨折时间、术前VAS评分、有无抑郁症病史均存在显著性差异(P<0.05)。Logistic回归分析显示骨折时间长、术前VAS评分低、有抑郁症病史为PVP术后24 h患者不满意的独立危险因素。可见PVP术后手术效果与患者骨折时间、术前VAS评分、有无抑郁症病史有关;骨折时间≤3周、术前VAS评分≥7分、无抑郁症的患者手术效果好,患者满意度更高。     

针灸学科当前的机遇与挑战

 针灸已经成为世界上应用最为广泛的替代医学疗法，针灸走向国际也给针灸学科发展带来了诸多挑战和机遇。概述了针灸研究取得的最新进展以及针灸学科面临的挑战，并阐述了针灸国际化带来的发展机遇。     

《黄帝内经》“心痛”一词的英译

基于中医术语的英译原则,比较《黄帝内经·素问》所载“心痛”一词的英译。通过文献考证, 比较分析国内外常用中医术语词典和四部《素问》译本中关于“心痛”的翻译。目前中医术语标准化工作虽然已经取得了较大的进展,但对中医古籍的翻译仍需完善,希冀为中医药的对外交流产生积极影响。     

"住痛移疼、取相交相贯之迳"的临床应用

以针刺百会、下龈交为相交相贯之经穴,配合曲泉,委中刺血等治法,治疗急慢性前列腺炎、睾丸炎、膀胱炎、阴道炎和痛经等病,有住痛止疼、利湿热、解毒等功效,可用于治疗多种泌尿生殖病症,疗效确切。     

ω-芋螺毒素MVIIA和MVIIC对α9α10乙酰胆碱受体的活性研究

分析和检测了ω-芋螺毒素MVIIA和MVIIC对α9α10乙酰胆碱受体(nAChR)的结合活性,并用重组表达在非洲爪蟾卵母细胞膜上的大鼠α9α10 nAChR受体,分别评价了2个ω-芋螺毒素MVIIA和MVIIC在常规的ND96灌流液和不含钙离子的钡离子ND96灌流液(Ba2+ND96)中对该受体的阻断活性.研究表明,2个ω-芋螺毒素MVIIA和MVIIC在Ba2+ND96灌流液中对α9α10 nAChR没有抑制作用,而它们在常规的ND96灌流液中却表现出微弱的抑制活性,这应是受钙离子激活产生的氯离子电流影响的结果.因此,2个ω-芋螺毒素MVIIA和MVIIC并不是α9α10 nAChR的有效阻断剂,其作用机理与α-芋螺毒素Vc1.1和Rg IA完全不同.本研究阐明了芋螺毒素抑制α9α10 nAChR和钙离子通道的机理,这对研发新型的芋螺毒素镇痛药和更好地治疗顽固性疼痛具有很重要的科学意义.     

基于SVM的新生儿疼痛表情识别

近十年来新生儿疼痛引起医护人员的广泛关注.由于新生儿不能自述疼痛的感受,疼痛评估成为新生儿科学中最具挑战性的一个难题.新生儿"疼痛面容"(蹙眉、挤眼、鼻唇沟加深、张口)被认为是最可靠的疼痛指标,且持续时间最长,因而被国际上常用的新生儿疼痛评估工具作为评估指标.然而,这些疼痛评估工具往往受到临床医护人员主观因素的影响.文中旨在解决上述问题,提出利用支持向量机(SVM)技术对新生儿疼痛与非疼痛面部表情进行分类识别.对210幅照片的表情图像进行了研究,比较了线性核函数SVM、多项式核函数SVM(d=2,3,4)以及径向基函数SVM等5种不同分类器的性能.实验结果表明,阶数d=3的多项式核函数SVM分类器的性能最佳,对疼痛和非疼痛表情分类的识别率达到93.33%,对疼痛与安静表情的分类识别率为94.17%,对疼痛与哭表情的分类识别率为83.13%,初步具备了在新生儿疼痛评估中的潜在应用价值.     

Things behind A War——An analysis of Two Soldiers

Different people will react to war differently.In this essay,we will see three kinds of feelings to the WWII,or to any war.Some people are very active and volunteer to fight for something they love.Some people are in fear of losing their loved ones but they also can understand the importance of some wars.Some people are very passive to any war,finding no meaning.The discussion is about these attitudes.There is more behind the war for people to think about,too.     

Purinergic systems in microglia

Accumulating findings indicate that nucleotides play an important role in microglia through P2 purinoceptors. P2 purinoceptors are divided into two families, ionotropic receptors (P2X) and metabotropic receptors (P2Y). P2X receptors (7 types; P2X₁ – P2X₇) contain intrinsic pores that open by binding with ATP. P2Y receptors (8 types; P2Y_{1, 2, 4, 6, 11, 12, 13 and 14}) are activated by nucleotides and couple to intracellular second-messenger systems through heteromeric G-proteins. Nucleotides are released or leaked from non-excitable cells as well as neurons in physiological and pathophysiological conditions. Microglia express many types of P2 purinoceptors and are known as resident macrophages in the CNS. ATP and other nucleotides work as ‘warning molecules’ especially through activating microglia in pathophysiological conditions. Microglia play a key role in neuropathic pain, chemotaxis and phagocytosis through nucleotide-evoked activation of P2X₄, P2Y₁₂ and P2Y₆ receptors, respectively. These findings indicate that extracellular nucleotides are important players in the central stage of microglial function. Received 19 April 2008; received after revision 20 May 2008; accepted 23 May 2008     

一种可用于条件性位置偏爱实验的疼痛大鼠模型

目的:建立大鼠背部切口疼痛模型,以条件性位置偏爱实验(CPP)观察大鼠对止痛药对乙酰氨基酚作用的主观反应。方法:在大鼠右下背部定位作手术切口并缝合后,以对乙酰氨基酚100 mg/kg伴药适应4次,每次间隔12 h,观察适应前后大鼠CPP值的变化。结果:切口痛大鼠在伴药适应后对伴药箱CPP值显著增加,而非手术用药大鼠及未用药对照组大鼠的CPP值变化无显著意义。结论:背部切口痛大鼠模型可以用于CPP实验,有助于观察大鼠对镇痛药的奖赏效应以及实验者评估动物对疼痛的主观不愉快感受。     

Firewalking

Summary Firewalking is known throughout recorded history and around the world. Ordinarily it is associated with religious beliefs or mystical states of mind in which the gods or unusual mental powers provide extraordinary protection for true believers or those with proper training. However, firewalking commonly involves hot materials of low heat capacity and poor thermal conductivity and sometimes the use of insulation. The excited or trance-like states of firewalkers contribute to the firewalkers' subjective experience but are not required for a successful walk. We conclude that elementary knowledge of physics and psychology is sufficient to explain the known observations of firewalking.