重力式抗滑挡墙最优截面的模式搜索法

在满足安全要求的前提下,为了减少重力式抗滑挡墙的材料用量,降低工程造价,以抗滑挡墙的几何参数为优化变量,以截面面积为优化目标函数,在满足抗滑移、抗倾覆和地基承载力等约束条件的基础上,建立了重力式抗滑挡墙的优化模型,并用Hooke-Jeeves模式搜索算法求解,并编制了优化设计程序.通过对某抗滑挡墙的优化分析,结果表明:采用本文方法对重力式抗滑挡墙进行优化,在满足安全的条件下可以明显的降低工程费用,在滑坡治理工程中具有一定的实用价值.     

o/w微乳液中制备甲基丙烯甲酯-苯乙烯共聚物超细颗粒

在甲基丙烯酸甲酯（ＭＭＡ）－苯乙烯－环己烷／十六烷基三甲基溴化铵（ＣＴＡＢ）／水体系的ｏ／ｗ微乳液中,制备了粒径约５８ｎｍ球状甲基丙烯酸甲酯－苯乙烯共聚物超细颗粒,研究了影响粒子形态和大小的因素。     

底部两层框架抗震墙砖房抗震设计的初步探讨

就底部两层框架抗震墙砖房抗震设计的几个问题,提出底部两层框架抗震墙体系的合理布置,过渡楼层抗剪抗弯能力应适当增强,以及构造措施等。     

人工神经网络在油田注采量描述中的应用

考虑油田注水开发期采液量是注水参数和地层参数等的连续函数,应用人工神经网络技术,探讨油田注水开发期见水后的各个单井产状描述和产液量预测的新方法．采用某油田某区块内５口采油井配置１０口注水井,在１２个月的注采数据来训练所建立的注采系统人工神经网络模型．结果表明,人工神经网络可很好地用来定量描述油田注水期采出液量与注入液量之间的复杂函数关系,可用于油田水驱产状的描述．滚动预测的结果表明,预测的累计采油量随月份的增长变化和实测的符合良好．     

Antiproliferative effects of 4′, 5′-unsaturated adenine nucleosides on leukemia L 1210 cells in vitro

Summary Several 4w336338146w7w50g/xxlarge8242.gif" alt="prime" align="BASELINE" BORDER="0">, 5w336338146w7w50g/xxlarge8242.gif" alt="prime" align="BASELINE" BORDER="0">-unsaturated adenine nucleosides were shown to have antiproliferative activity against L 1210 leukemia cells in vitro. The active nucleosides were cytotoxic to the L 1210 cells as demonstrated by Trypan Blue uptake. The cytotoxicity was not induced by alterations in the ribonucleoside and deoxyribonucleoside triphosphate levels of the L 1210 cells.     

Novel rearrangement of purines

Summary 6-Trichloromethyl-9-methylpurine (1) rearranges to 6-dichloromethyl-9-methyl-8-oxopurine (2) in aqueous mild acidic solution. The rearrangement is rationalized in terms of a reaction involving protonation, covalent hydration, prototropic equilibrium and/or a hydride transfer. An alternative mechanism involving a w54472q035661x6q/xxlarge8216.gif" alt="lsquo" align="BASELINE" BORDER="0">positivew54472q035661x6q/xxlarge8217.gif" alt="rsquo" align="BASELINE" BORDER="0"> halogen compound and hypochlorous acid as an intermediary is also proposed. Compound1 condenses with 4,5-diaminopyrimidine to give the purine-pyrimidine Schiff base pair4.Acknowledgments. We are deeply indebted to Professor S. Cohen of the Sackler School of Medicine, Tel Aviv University (Ramat Aviv, Isreal) for his advice and encouragement. Support of this research by the Israel Cancer Association, the Ber-Lamsdorf Foundation Switzerland Israel and by the Advancement of Mankind Foundation, is gratefully acknowledged. We thank Proff. D. Arigoni and A. Eschenmoser, ETH Zürich, for their valuable proposals and comments on the mechanism of the rearrangement.     

Alzheimer's disease: fundamental and therapeutic aspects

Alzheimer's disease is the most common type of progressive and debilitating dementia affecting aged people. In some early — as well as late-onset familial cases, a genetic linkage with chromosomes 14, 21 (early-onset) or 19 (late-onset) has been indicated. Furthermore, a direct or indirect role has been attributed to normal or structurally altered amyloid w45081q372/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-protein (concentrated in senile plaques) and/or excessively phosphorylated tau protein (located in neurofibrillary tangles). Degeneration of cholinergic neurons and concomitant impairment of cortical and hippocampal neurotransmission lead to cognitive and memory deficits. Several compounds are being tested in attempts to prevent and/or cure Alzheimer's disease, including tacrine, which has very modest efficacy in a sub-group of patients, and new acetylcholinesterase inhibitors. Pilot experiments have also been launched using nerve growth factor (NGF) to prevent or stabilize the processes of cholinergic pathway degeneration. Alternatively, antioxidants, free radical scavengers and/or non steroidal anti-inflammatory agents may be screened as potential therapies for neurodegenerative diseases induced by multiple endogenous and/or exogenous factors. The recent use of transgenic mice, in parallel with other genetic, biochemical and neurobiological systems, in vivo and/or in vitro (cell cultures), should accelerate the discovery and development of specific drugs for the treatment of Alzheimer's disease.     

17β-Estradiol-sensitivity of cultured myometrial cells

Summary The estrogen sensitivity of cells cultured from the rat myometrium was studied by growing the cells in the absence or presence of 1 nM 17w35329/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-estradiol. Following a time lag of w35329/xxlarge8764.gif" alt="sim" align="MIDDLE" BORDER="0">10 days, exposure to estrogen resulted in increased incorporation of radiothymidine by the cells. Estrogen treatment also decreased isoproterenol-dependent and GTP-dependent adenylate cyclase activity, but had no effect on basal activity. These cultured cells have been shown previously to have some properties of uterine smooth muscle. The effects estrogen has in viyro, therefore, may reflect important properties in vivo that account for the mechanism by which the sex steroid decreases the sensitivity of the myometrium to isoproterenol.     

介质覆盖曲面上非镜面波散射研究

提出一种表面爬行波新概念，并运用此概念，研究介质覆盖导电曲表面上非镜面波的散射特性、覆盖介质的电磁参数和涂层厚度变化时覆盖介质对表面爬行波散射抑制作用的变化趋势。     

原油乳状液液滴建模与小变形动力学分析

从微观角度出发,根据运动学基本定律,建立乳状液液滴受力模型,同时进行了乳状液液滴的小变形动力学分析,并进行了模型求解和仿真,为原油电脱水的自动控制提供了理论基础。