Simulating FAS-induced apoptosis by using P systems

In contrast to differential equations, P systems are an unconventional model of computation which takes into consideration the discrete character of the quantity of components and the inherent randomness that exists in biological phenomena. The key feature of P systems is their compartmentalised structure which represents the heterogeneity of the structural organisation of the cells, and where one can take into account the role played by membranes in the functioning of the system, for example signalling at the cell surface, selective uptake of substances from the media, diffusion across different compartments, etc. We show here that P systems can be a reliable tool for Systems Biology and could even outperform in some cases the current simulation techniques based on differential equations. We will also use a strategy based on the well known Gillespie algorithm but running on more than one compartment called Multi-compartmental Gillespie Algorithm.     

Genetic background of phenotypic variation

A noteworthy feature of the living world is its bewildering variability. A key issue in several biological disciplines is the achievement of an understanding of the hereditary basis of this variability. Two opposing, but not necessarily irreconcilable conceptions attempt to explain the underlying mechanism. The gene function paradigm postulates that phenotypic variance is generated by the polymorphism in the coding sequences of genes. However, comparisons of a great number of homologous gene and protein sequences have revealed that they predominantly remained functionally conserved even across distantly related phylogenic taxa. Alternatively, the gene regulation paradigm assumes that differences in the cis-regulatory region of genes do account for phenotype variation within species. An extension of this latter concept is that phenotypic variability is generated by the polymorphism in the overall gene expression profiles of gene networks. In other words, the activity of a particular gene is a system property determined both by the cis-regulatory sequences of the given genes and by the other genes of a gene network, whose expressions vary among individuals, too. Novel proponents of gene function paradigm claim that functional genetic variance within the coding sequences of regulatory genes is critical for the generation of morphological polymorphism. Note, however, that these developmental genes play direct regulatory roles in the control of gene expression.     

┱?例杨金彪;福建省南平市第

鸨?114尼美舒利致肝功能损伤1例陈瑶;李岚;厦门市妇幼保健院药剂科,上海儿童医学中心药剂科 厦门361000,上海200000尼美舒利;;肝功能损害0海峡药学Strait Pharmaceutical Journal118-119R725.9E06938E;E069_38陈瑶;114-115门诊药房实行专科药师制度的必要性陈成辉;何丽芳;     

Self-Dual Hadamard Bent Sequences

A new notion of bent sequence related to Hadamard matrices was introduced recently,motivated by a security application(Solé, et al., 2021). The authors study the self-dual class in length at most 196. The authors use three competing methods of generation: Exhaustion, Linear Algebra and Gr?bner bases. Regular Hadamard matrices and Bush-type Hadamard matrices provide many examples. The authors conjecture that if v is an even perfect square, a self-dual bent sequence of length v always exists. The ...     

RSS拓补结构机座的动态优化

以燃气轮机透平端RSS(旋转对称支承板)机座为研究背景,通过用D’Alembert原理建立了RSS机座的拓补优化域和等价边界条件,从而实现了用均匀化方法的RSS机座拓扑结构优化,得到了旋转对称的弧形支承板拓扑结构的机座.然后,结合原来RSS机座的机构特征在ANSYS workbench中建立了RSS拓补结构光滑有限元模型,并进行了工作条件下的模态分析,以前三阶模态振型中轴承座的振型作为当量静载荷加载到原模型对比计算,验证边界条件的正确性.以RSS机座弧形支承板的四个关键尺寸为设计变量,以机座的变形量和应力为目标函数,进行了随频率变化的动态优化设计.通过优化改变了RSS拓补结构的动态特性,使固有频率远离了工作频率.     

渥沦斯基形象再探讨

一俄国批判现实主义文学大师列夫·托尔斯泰在《安娜·卡列尼娜》中围绕社会家庭问题塑造了一系列人物形象 ,渥沦斯基是其中之一。对渥沦斯基的认识 ,评论家们莫衷一是 ,有人说他是“彼得堡花花公子的最好标本” ,一如卡列宁 ,不过是反其道而行之。卡列宁用僵死的说教窒杀安娜的生命力 ,渥沦斯基则以热烈的感情来俘虏安娜的心灵。前者缺少爱 ,后者的爱却是浅薄而浮夸的。卡列宁把安娜当成妻子而不当成女人 ,渥沦斯基则是把他当成女人而不当成妻子。在本质上 ,他们俩人都是仇视人的天赋感情与纯真的情操的。这样评价渥沦斯基显然是有失公平的…     

知识经济时代的企业专利战略

知识经济是建立在知识和信息的占有、生产、分配和应用之上的新型经济,其核心问题是知识产权。作为知识产权重要组成部分的专利权,即由国家对具备专利条件的发明创造授予的具有有效期内的专有权,其目的是阻止他人侵权,保护专利人的正当权益。现在,企业之间的竞争日趋激烈,各个企业都在不断努力生产和销售新产品,不断提高     

Microstructural evaluation and nanohardness of an AlCoCuCrFeNiTi high-entropy alloy

An AlCoCuCrFeNiTi high-entropy alloy(HEA) was prepared by mechanical alloying and sintering to study the effect of Ti addition to the widely studied AlCoCuCrFeNi system. The structural and microstructural characteristics were investigated by X-ray diffraction(XRD), scanning electron microscopy(SEM), and transmission electron microscopy(TEM). The formation of four micrometric phases was detected: a Cu-rich phase with a face-centered cubic(fcc) structure, a body-centered cubic(bcc) solid solution with Cu-rich plate-like precipitates(fcc), an ordered bcc phase, and a tetragonal structure. The XRD patterns corroborate the presence of a mixture of bcc-, fcc-, and tetragonal-structured phases. The Vickers hardness of the alloy under study was more than twice that of the AlCoCuCrFeNi alloy. Nanoindentation tests were performed to evaluate the mechanical response of the individual phases to elucidate the relationship between chemical composition, crystal structure, and mechanical performance of the multiphase microstructure of the AlCoCuCrFeNiTi HEA.     

一种基于CloudSim的分级云存储仿真模型

随着云存储技术的发展,云存储平台解决了大数据存储与管理的难题。然而当数据量与用户量进一步扩大,系统性能要求逐步提升,需要对目前云存储环境中的数据存储管理技术进行深入的研究与改进。由于应用实际的云存储集群进行优化研究极易受到平台环境的限制,因此基于CloudSim实现了一个分级云存储的仿真模型TCSS,给出了一种三层次的设备分级组织结构,构建了完善的数据I/O业务处理与数据存储管理等功能结构。已经将所有拓展功能模块集成到了CloudSim仿真工具的CloudSim层中,用户可以依据TCSS模型,突破平台限制,完成云存储优化策略的建模与测试工作。