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81.
报道了改革后新剂型—小儿化食口服液对动物的消化功能的影响(包括离体肠段的收缩性、小肠推进运动、胃蛋白酶活性等)。结果显示小儿化食口服液与原剂型小儿化食丸药理作用基本相似,且在对胃蛋白酶活性的影响等方面优于丸剂。本实验对该药剂型改革提供了药理学依据。 相似文献
82.
Integrin antagonists 总被引:4,自引:0,他引:4
Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are
involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood
clotting and immune response. Aberrant cell adhesion has been implicated in the pathogenesis of several diseases, including
a number of inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and asthma, as well as cancer
and coronary heart disease. As such integrins are seen as excellent targets for the development of therapeutic agents. This
report begins with an examination of the structure of integrin molecules and their ligands and then goes on to review the
current state of development of antiintegrin antagonists.
Received 13 April 1999; received after revision 28 May 1999; accepted 28 May 1999 相似文献
83.
Mangold U 《Cellular and molecular life sciences : CMLS》2006,63(18):2095-2101
In contrast to the considerable interest in the oncogene ornithine decarboxylase (ODC) and in the family of antizymes with
regard to cell proliferation and tumorigenesis, the endogenous antizyme inhibitor (AZI) has been less well studied. AZI is
highly homologous to the enzyme ODC but does not possess any decarboxylase activity. Elevated ODC activity is associated with
most forms of human malignancies. Antizymes bind ODC, inhibit ODC activity and promote the ubiquitin-independent degradation
of ODC. Consequently they are proposed as tumor suppressors. In particular, the most studied member of the antizyme family,
antizyme 1, has been demonstrated to play a role in tumor suppression. AZI inactivates all members of the antizyme family,
reactivates ODC and prevents the proteolytic degradation of ODC, which may suggest a role for AZI in tumor progression.
Received 9 December 2005; received after revision 13 April 2006; accepted 1 June 2006 相似文献
84.
HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains 总被引:4,自引:0,他引:4
Jiang JL Chan HC Zhou Q Yu MK Yao XY Lam SY Zhu H Ho LS Leung KM Chen ZN 《Cellular and molecular life sciences : CMLS》2004,61(16):2083-2091
HAb18G/CD147 is a heavily glycosylated protein containing two immunoglobulin superfamily domains. Our previous studies have indicated that overexpression of HAb18G/CD147 enhances metastatic potentials in human hepatoma cells by disrupting the regulation of store-operated Ca2+ entry by nitric oxide (NO)/cGMP. In the present study, we investigated the structure-function of HAb18G/CD147 by transfecting truncated HAb18G/CD147 fragments into human 7721 hepatoma cells. The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721C and T7721N cells, respectively. The potential effect of HAb18G/CD147 on metastatic potentials, both adhesion and invasion capacities, of hepatoma cells was abolished in T7721C cells, but not affected in T7721N cells. Release and activation of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, were found to be enhanced by the expression of HAb18G/CD147, and this effect was abolished by both truncations. Thapsigargin significantly enhanced release and activation of MMPs (MMP-2 and MMP-9) in non-transfected 7721 cells, and this effect was negatively regulated by SNAP. However, no effects of thapsigargin or SNAP were observed in T7721 cells, and expression of HAb18G/CD147 enhanced secretion and activation of MMPs at a stable and high level. Taken together, these results suggest that both ectodomain and intracellular domains of HAb18G/CD147 are required to mediate the effect of HAb18G/CD147 on the secretion and activation of MMPs and metastasis-related processes in human hepatoma cells by disrupting the regulation of NO/cGMP-sensitive intracellular Ca2+ mobilization although each domain may play different roles.Received 1 April 2004; received after revision 15 June 2004; accepted 22 June 2004 相似文献
85.
Breast cancer still remains a major problem in its incidence, morbidity and mortality; therefore, more effective strategies for its prevention are urgently needed. Retinoids, natural and synthetic derivatives of vitamin A, possess antiproliferative and proapoptotic properties, making them a promising class of chemopreventive agents against breast cancer. The efficacy of all-trans retinoic acid, 9-cis-retinoic acid, LGD1069 (Targretin, bexarotene), and N-(4-hydroxyphenyl)retinamide (fenretinide) as breast cancer chemopreventive agents is being studied. A better understanding of the molecular mechanisms of action of these agents should lead to improvements in their clinical application. In this review, we discuss the mechanisms by which retinoids exert their antiproliferative and apoptotic effects in breast cancer cells.Received 5 January 2004; received after revision 9 February 2004; accepted 12 February 2004 相似文献
86.
87.
Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of α-lactalbumin 总被引:1,自引:0,他引:1
Apoptosis is essential to eliminate secretory epithelial cells during the involution of the mammary gland. The environmental regulation of this process is however, poorly understood. This study tested the effect of HAMLET (human -lactalbumin made lethal to tumor cells) on mammary cells. Plastic pellets containing HAMLET were implanted into the fourth inguinal mammary gland of lactating mice for 3 days. Exposure of mammary tissue to HAMLET resulted in morphological changes typical for apoptosis and in a stimulation of caspase-3 activity in alveolar epithelial cells near the HAMLET pellets but not more distant to the pellet or in contralateral glands. The effect was specific for HAMLET and no effects were observed when mammary glands were exposed to native a-lactalbumin or fatty acid alone. HAMLET also induced cell death in vitro in a mouse mammary epithelial cell line. The results suggest that HAMLET can mediate apoptotic cell death in mammary gland tissue.Received 30 January 2004; received after revision 5 March 2004; accepted 16 March 2004 相似文献
88.
89.
Our understanding of how immune responses are generated and regulated drives the design of possible immunotherapies for cancer
patients. For that reason, we first describe briefly the actual immunological theories and their common perspectives about
cancer vaccine development. Second, we describe cancer vaccines that are able to induce tumor-specific immune responses in
cancer patients. However, these responses are not always followed by tumor rejection. At the end of the review, we discuss
two possible reasons that might explain this dichotomy of cancer immunology. First, the immune response generated, although
detectable, may not be quantitatively sufficient to reject the tumor. Second, the tumor microenvironment may modulate tumor
cell susceptibility to the systemic immune response induced by the immunization. Finally, we discuss what, in our opinion,
might be the best way to improve cancer vaccine strategies and how the relationship between the tumor and its surroundings
might be studied in more details.
Received 21 June 2001; received after revision 15 August 2001; accepted 15 August 2001 相似文献
90.
FANGJianwu HUANGSiluo LIUHuisheng M.Crepin XUTao LIUJianfeng 《科学通报(英文版)》2003,48(15):1539-1547
Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor抯 intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer. 相似文献