问题探究学习的实践和体验

问题探究学习突出在“探究”中重视学生掌握数学知识，发展智力，培养能力，学会学习．创设情境，归纳类比，抽象概括，实验交流是提高探究能力的有效措施．实验表明，问题探究学习能够培养学生“再创造学习”能力，体现人文精神，使兴趣、发现、合作、创新的现代教育理念得以渗透．     

情境与探究教学模式的构建及实例分析

研究分析了情境与探究教学模式的内涵及具体实施过程.并以物理实验"用单摆测定重力加速度"为例进行了教学实践.结果表明,这种教学模式行之有效,符合新课程改革的教学理念.     

工艺规划系统中动态模式分类的研究

提出了工艺规划系统中动态模式分类（pattern classification）的概念，介绍了模式分类判定树和动态模式分类的基本原理，并对动态模式分类的聚类质量标准进行了研究。动态模式分类是基于实例归纳（case based reasoning,CBR)的自动分类过程，具有自学习和自完善的功能。     

一类按学生素质优劣排序的数学方法

用模糊学方法定量评定了学生的综合素质，并按素质的优劣给学生进行了排序，这里是将数学方法引入教学管理的初步尝试。     

在体育与健康课教学中培养学生创新能力的途径及方法

培养学生创新能力是体育与健康课教学融入教育改革的需要 ,依据创新学习的基本理论、学习模式及课堂特点 ,体育创新能力培养途径是 :培养体育创新的态度、培养体育创新的技能、培养体育创新的思维 .并提出了培养创新能力的方法     

关于高等教育职能取向问题的思考

随着高等教育的发展，高等教育的职能由原来单一的 教学职能发展到今天的教学、科研和社会服务等多种职能。在职能扩展的同时，高等教育职能的价值取向，也发生了从宗教化、神学化、精神化到世俗化、物质化、实用化的转变，这种取向上的变化有其深刻的历史必然性。但在目前高等教育职能价值取向转变的过程中，出现了一些偏差。只有纠正这种取向上的偏差，高等教育才能全面地完整地发挥自身的职能。     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.     

“互动分层合作学习”对田径运动成绩的影响

在田径教学实践中运用“互动合作学习法”对学生进行合理、适宜的分类或分组，确立相应的层次目标．做好课的设计，包括实践操作、课外作业、课内外的教学指导、协调学生组内及组间的合作交流等各个教学环节，使教学过程体现出系统性、层次性，使每位学生都能在各自力所能及的范围内，通过相互帮助和互相协作学习而收到良好的成效．同时能更好地促进学生主动、积极地学习，更好地完成教学任务与教学目标，提高教与学的双边效果．     

A NEW DESCRIPA NEW DESCRIPTOR OF AMINO ACIDS BASED ON THE THREEDIMENSIONAL VECTOR OF ATOMIC INTERACTION FIELD

QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) IS A VERY IMPORTANT TOPIC FOR MANY SCIENTIFIC FIELDS AND CAN BE TERMED AS QUANTITATIVE SEQUENCE ACTIVITY MODELS(QSAM)[1] WHEN REFERRED TO THE RESEARCH ON RELATION- SHIPS BETWEEN STRUCTURES AND ACTIVITIES OF BIOLOGICAL MOLECULES, SUCH AS PROTEINS, AND NUCLEIC ACIDS. HOW- EVER, IT IS VERY DIFFICULT TO ESTABLISH A QSAM MODEL,…     

椭圆偏振光理论中一个问题的证明

本文从椭偏光合矢量旋转角速度Ω的表达式出发，对只有沿椭圆长、短轴方向的椭偏光合矢量间的相位差才为的难点给出了证明